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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aipl1tvrm119
translational vision research model 119
MGI:5810589
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Aipl1tvrm119/Aipl1tvrm119 C57BL/6J-Aipl1tvrm119/Pjn MGI:5922030
ht2
 		Aipl1tvrm119/Aipl1tvrm127 C57BL/6J-Aipl1tvrm119/Aipl1tvrm127 MGI:5925360


Genotype
MGI:5922030
hm1
Allelic
Composition		 Aipl1tvrm119/Aipl1tvrm119
Genetic
Background		 C57BL/6J-Aipl1tvrm119/Pjn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aipl1tvrm119 mutation (1 available); any Aipl1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
retina photoreceptor degeneration ( J:243745 )
• rapid photoreceptor degeneration is not evident at 8 or 12 days of age, but by 1 month of age only one layer of photoreceptor nuclei remain

vision/eye
retina photoreceptor degeneration ( J:243745 )
• rapid photoreceptor degeneration is not evident at 8 or 12 days of age, but by 1 month of age only one layer of photoreceptor nuclei remain
abnormal electroretinogram waveform feature ( J:243745 )
• dark-adapted ERG response amplitudes are reduced at 18 days of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Leber congenital amaurosis 4 DOID:0110332 OMIM:604393
 J:243745




Genotype
MGI:5925360
ht2
Allelic
Composition		 Aipl1tvrm119/Aipl1tvrm127
Genetic
Background		 C57BL/6J-Aipl1tvrm119/Aipl1tvrm127
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aipl1tvrm119 mutation (1 available); any Aipl1 mutation (29 available)
Aipl1tvrm127 mutation (1 available); any Aipl1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
retina photoreceptor degeneration ( J:243745 )
• rapid retinal photoreceptor degeneration evident at 1 month of age

vision/eye
retina photoreceptor degeneration ( J:243745 )
• rapid retinal photoreceptor degeneration evident at 1 month of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory