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Allele Symbol Allele Name Allele ID |
Tg(Mt1-TGFBR2*)AM3Epb transgene insertion AM3, Erwin P Bottinger MGI:5806465 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are protected against pancreatic lesion formation
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• mice are protected against pancreatic lesion formation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• expansion of the pancreatic stroma
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• pancreatic lesions are accompanied with more severe fibrosis and heavy matrix deposition
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• mice develop pancreatic acinar-to-ductal metaplasia
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• mice show extensive intraductal papillary neoplasm development and associated parenchymal loss
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• increase in proliferating cell nuclear antigen (PCNA) staining throughout the entire pancreas
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• mice display marked pancreatic inflammation
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• total T-cell infiltration near pancreatic lesions is increased, with increased CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration but very little CD8+ infiltration
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• mice display marked pancreatic inflammation
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• total T-cell infiltration near pancreatic lesions is increased, with increased CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration but very little CD8+ infiltration
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• mice show extensive intraductal papillary neoplasm development and associated parenchymal loss
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| pancreatic carcinoma | DOID:4905 |
OMIM:260350 |
J:231759 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• acini are replaced by primitive ductular structures harboring transitional cells, characterized by ductal morphology but containing zymogen granules
• tubular complexes resulting from dedifferentiation of acini into ductal structures are present in severely affected pancreatic lobules with increasing age
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• pancreas exhibits adipose replacement of acini in the exocrine pancreas
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• 21% of 14 month or older mutants exhibit eosinophilic foci of acinar cells, indicating focal hyperplasia
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• pancreas shows ductular transformation
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• increase in the proportion of proliferating acinar cells in the pancreas at 6 weeks and 8 months of age
• however, aberrant ductular epithelial cells in the pancreas do not show evidence of increased proliferative activity
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• pancreas is lighter in color at 5 months of age
• pancreas shows neo-angiogenesis
• expansion of the extracellular matrix in the pancreas of 8 month old mice
• however, islets of Langerhans are normal
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• acini are replaced by primitive ductular structures harboring transitional cells, characterized by ductal morphology but containing zymogen granules
• tubular complexes resulting from dedifferentiation of acini into ductal structures are present in severely affected pancreatic lobules with increasing age
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• pancreas exhibits adipose replacement of acini in the exocrine pancreas
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• 21% of 14 month or older mutants exhibit eosinophilic foci of acinar cells, indicating focal hyperplasia
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• pancreas shows ductular transformation
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• relative pancreatic weight is decreased at 8 months of age
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• inter- and intralobular fibrosis develops by 5 months of age and increases progressively
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• acino-ductal metaplasia is seen in some young mice and are frequently seen in older mice, often transforming entire lobules
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• large numbers of apoptotic cells are seen in the pancreas of 6 week old mice
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• increase in the proportion of proliferating acinar cells in the pancreas at 6 weeks and 8 months of age
• however, aberrant ductular epithelial cells in the pancreas do not show evidence of increased proliferative activity
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• increase in macrophage infiltration in the pancreas
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• increase in macrophage infiltration in the pancreas
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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