Phenotypes associated with this allele

• Allele Symbol: Gpr18^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmeceuticals
• Allele ID: MGI:5788557
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpr18^tm1Lex/Gpr18^tm1Lex	involves: 129S/SvEv * C57BL/6	MGI:5896998

Genotype
MGI:5896998

hm1

• Allelic Composition: Gpr18^tm1Lex/Gpr18^tm1Lex
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to bacterial infection ( J:226433 )

• Escherichia coli-infected mice exhibit higher polymorphonuclear neutrophils (PMN), reduced specialized pro-resolving mediator (SPM), impaired efferocytosis, and delayed resolution of infection compared with wild-type mice

homeostasis/metabolism

increased susceptibility to injury ( J:226433 )

• Escherichia coli-infected mice exhibit reduced phagocyte responses to RvD2 compared with wild-type mice

• Staphylococcus aureus-infected mice treated with RvD2 fail to exhibit a reduction in bacterial titers and PMN numbers unlike wild-type mice

• following ischemia by hindlimb occlusion and reperfusion, mice treated with RvD2 fail to exhibit protection from second organ lung injury compared with wild-type mice