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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm5Mom
targeted mutation 5, Peter Mombaerts
MGI:5788276
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm5Mom/?
Or8a1tm28(cre)Mom/?
involves: 129P2/OlaHsd * C57BL/6 MGI:5788565


Genotype
MGI:5788565
cn1
Allelic
Composition
Gt(ROSA)26Sortm5Mom/?
Or8a1tm28(cre)Mom/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm5Mom mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Or8a1tm28(cre)Mom mutation (2 available); any Or8a1 mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
taste/olfaction
N
• axons of OLFR151 expressing olfactory sensory neurons appear to co-converge and coalesce in glomerular formation correctly despite G-protein disruption
• the olfactory sensory neurons expressing the dominant negative GNAS exhibit reduced numbers of spontaneous spikes and a significantly higher instantaneous firing frequency in perforated patch-clamp recordings

nervous system
• the olfactory sensory neurons expressing the dominant negative GNAS exhibit reduced numbers of spontaneous spikes and a significantly higher instantaneous firing frequency in perforated patch-clamp recordings

respiratory system
• the olfactory sensory neurons expressing the dominant negative GNAS exhibit reduced numbers of spontaneous spikes and a significantly higher instantaneous firing frequency in perforated patch-clamp recordings





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory