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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(IgkH280)934Dvs
transgene insertion 934, David V Serreze
MGI:5752042
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Emv30b/Emv30b
Prkdcscid/Prkdcscid
Tg(IghH280)48Dvs/?
Tg(IgkH280)934Dvs/? 		NOD.Cg-Emv30b Prkdcscid Tg(IghH280)48Dvs Tg(IgkH280)934Dvs/Dvs MGI:6303746
cx2
 		Tg(IghH280)48Dvs/?
Tg(IgkH280)934Dvs/? 		NOD/ShiLtDvs-Tg(IghH280)48Dvs Tg(IgkH280)934Dvs/Dvs MGI:6303754
tg3
 		Tg(IgkH280)934Dvs/? NOD/ShiLtDvs-Tg(IgkH280)934Dvs/J MGI:5752048


Genotype
MGI:6303746
cx1
Allelic
Composition		 Emv30b/Emv30b
Prkdcscid/Prkdcscid
Tg(IghH280)48Dvs/?
Tg(IgkH280)934Dvs/?
Genetic
Background		 NOD.Cg-Emv30b Prkdcscid Tg(IghH280)48Dvs Tg(IgkH280)934Dvs/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emv30b mutation (3 available); any Emv30 mutation (3 available)
Prkdcscid mutation (171 available); any Prkdc mutation (408 available)
Tg(IghH280)48Dvs mutation (0 available)
Tg(IgkH280)934Dvs mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:274578 )
N
• mice homozygous for the scid mutation do not develop insulitis despite the NOD background and pro-diabetic transgenes




Genotype
MGI:6303754
cx2
Allelic
Composition		 Tg(IghH280)48Dvs/?
Tg(IgkH280)934Dvs/?
Genetic
Background		 NOD/ShiLtDvs-Tg(IghH280)48Dvs Tg(IgkH280)934Dvs/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghH280)48Dvs mutation (0 available)
Tg(IgkH280)934Dvs mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system




Genotype
MGI:5752048
tg3
Allelic
Composition		 Tg(IgkH280)934Dvs/?
Genetic
Background		 NOD/ShiLtDvs-Tg(IgkH280)934Dvs/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IgkH280)934Dvs mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
insulitis ( J:274578 )
• mice develop insulitis earlier than NOD/ShiLtDvs controls

immune system
insulitis ( J:274578 )
• mice develop insulitis earlier than NOD/ShiLtDvs controls
increased susceptibility to autoimmune diabetes ( J:274578 )
• 90-95% of mice develop type 1 diabetes by 20 weeks of age
• onset is accelerated as compared to NOD/ShiLtDvs controls (80-90% by 30-40 weeks of age)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory