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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ubiad1tm1.1Thka
targeted mutation 1.1, Toshio Okano
MGI:5707728
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ubiad1tm1.1Thka/Ubiad1tm1.1Thka C57BL/6-Ubiad1tm1.1Thka MGI:5707764
ht2
Ubiad1tm1.1Thka/Ubiad1+ C57BL/6-Ubiad1tm1.1Thka MGI:5707765


Genotype
MGI:5707764
hm1
Allelic
Composition
Ubiad1tm1.1Thka/Ubiad1tm1.1Thka
Genetic
Background
C57BL/6-Ubiad1tm1.1Thka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubiad1tm1.1Thka mutation (0 available); any Ubiad1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• although present at E7.5, no mice are present at E10.5
• however, treatment with menaquinone 4 or coenzyme Q10 extends lifespan to E15.5 in some embryos and P1 in others

embryo
• absence of the constriction marking the extraembryonic-embryonic ectoderm border
• at E7.5
• however, treatment with MK-4 rescues embryo size

homeostasis/metabolism
• mice are unable to synthesize menaquinone 4 (MK-4)
• however, mice are able to synthesize coenzyme Q9 (CoQ9)

growth/size/body
• at E7.5
• however, treatment with MK-4 rescues embryo size




Genotype
MGI:5707765
ht2
Allelic
Composition
Ubiad1tm1.1Thka/Ubiad1+
Genetic
Background
C57BL/6-Ubiad1tm1.1Thka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubiad1tm1.1Thka mutation (0 available); any Ubiad1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice exhibit normal serum levels of calcium, phosphorus, glucose, LDL cholesterol and triglycerides
• total and free at 28 weeks
• tissue levels of menaquinone 4 (MK-4) and its epoxide are half of wild-type at P28
• reduced MK-4 synthetic activity in the cerebrum and mouse embryonic fibroblasts
• however, coenzyme Q9 and E10 levels are normal





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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory