Phenotypes associated with this allele

• Allele Symbol: Brpf1^{tm1d(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1d, Wellcome Trust Sanger Institute
• Allele ID: MGI:5705132
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brpf1^tm1d(EUCOMM)Wtsi/Brpf1^tm1d(EUCOMM)Wtsi	involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N	MGI:5902766
hm2	Brpf1^tm1d(EUCOMM)Wtsi/Brpf1^tm1d(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:5896565
ht3	Brpf1^tm1d(EUCOMM)Wtsi/Brpf1^+	involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N	MGI:5902767

Genotype
MGI:5902766

hm1

• Allelic Composition: Brpf1^{tm1d(EUCOMM)Wtsi}/Brpf1^{tm1d(EUCOMM)Wtsi}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
• Cell Lines: EPD0069_1_G06

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:240552 )

• reduced histone H3K23 acetylation in extracts and mouse embryonic fibroblasts

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
syndromic intellectual disability		DOID:0050888		J:240552

Genotype
MGI:5896565

hm2

• Allelic Composition: Brpf1^{tm1d(EUCOMM)Wtsi}/Brpf1^{tm1d(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0069_1_G06

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:222304 )

• almost no viable pups are born and no normal embryos are recovered after E9.5, suggesting embryonic lethality around E9.5

Genotype
MGI:5902767

ht3

• Allelic Composition: Brpf1^{tm1d(EUCOMM)Wtsi}/Brpf1⁺
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
• Cell Lines: EPD0069_1_G06

cellular

abnormal cell physiology ( J:240552 )

• reduced histone H3K23 acetylation in E10.5 embryos