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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Brpf1tm1d(EUCOMM)Wtsi
targeted mutation 1d, Wellcome Trust Sanger Institute
MGI:5705132
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Brpf1tm1d(EUCOMM)Wtsi/Brpf1tm1d(EUCOMM)Wtsi involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N MGI:5902766
hm2
Brpf1tm1d(EUCOMM)Wtsi/Brpf1tm1d(EUCOMM)Wtsi involves: C57BL/6J * C57BL/6N MGI:5896565
ht3
Brpf1tm1d(EUCOMM)Wtsi/Brpf1+ involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N MGI:5902767


Genotype
MGI:5902766
hm1
Allelic
Composition
Brpf1tm1d(EUCOMM)Wtsi/Brpf1tm1d(EUCOMM)Wtsi
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
Cell Lines EPD0069_1_G06
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brpf1tm1d(EUCOMM)Wtsi mutation (0 available); any Brpf1 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• reduced histone H3K23 acetylation in extracts and mouse embryonic fibroblasts

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
syndromic intellectual disability DOID:0050888 J:240552




Genotype
MGI:5896565
hm2
Allelic
Composition
Brpf1tm1d(EUCOMM)Wtsi/Brpf1tm1d(EUCOMM)Wtsi
Genetic
Background
involves: C57BL/6J * C57BL/6N
Cell Lines EPD0069_1_G06
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brpf1tm1d(EUCOMM)Wtsi mutation (0 available); any Brpf1 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• almost no viable pups are born and no normal embryos are recovered after E9.5, suggesting embryonic lethality around E9.5




Genotype
MGI:5902767
ht3
Allelic
Composition
Brpf1tm1d(EUCOMM)Wtsi/Brpf1+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
Cell Lines EPD0069_1_G06
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brpf1tm1d(EUCOMM)Wtsi mutation (0 available); any Brpf1 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• reduced histone H3K23 acetylation in E10.5 embryos





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory