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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Pvalb-tdTomato/RNAi:Gad1)3Mirn
transgene insertion 3, Karoly Mirnics
MGI:5703933
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Pvalb-tdTomato/RNAi:Gad1)3Mirn/? C57BL/6-Tg(Pvalb-tdTomato/RNAi:Gad1)3Mirn MGI:5704175


Genotype
MGI:5704175
tg1
Allelic
Composition
Tg(Pvalb-tdTomato/RNAi:Gad1)3Mirn/?
Genetic
Background
C57BL/6-Tg(Pvalb-tdTomato/RNAi:Gad1)3Mirn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pvalb-tdTomato/RNAi:Gad1)3Mirn mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• freezing behavior is reduced by 20% as compared to 50% in wild-type controls
• mice spend more time investigating novel object as compared to controls
• increased physical interaction with novel object as compared to controls
• increased startle responses at low sound intensities
• decreased rearing in response to ketamine (an NMDA antagonist) at 5 mg/kg dose as compared to wild-type
• increased rearing in response to ketamine (an NMDA antagonist) at 2.5 mg/kg dose as compared to wild-type
• increased preference for social novelty (new mouse) versus familiar mouse

nervous system
• reduction in spontaneous inhibitory postsynaptic currents (sIPSCs) frequency measured in pyramidal neurons from Layer V of the prelimbic region of the prefrontal cortex
• however, amplitude and kinetics are not changed
• impaired prepulse inhibition as assessed by lack of startle response with increased sound intensities





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory