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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Cd74-Nlrc4*)1Kyas
transgene insertion 1, Koji Yasutomo
MGI:5696384
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Cd74-Nlrc4*)1Kyas/0 involves: C57BL/6N MGI:5696385


Genotype
MGI:5696385
tg1
Allelic
Composition
Tg(Cd74-Nlrc4*)1Kyas/0
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

immune system
• mice show increased numbers of CD11b+Gr1+ neutrophils
• most cells that produce Il17a are neutrophils
• mice how increased numbers of activated T cells
• spleen shows a 15-fold increase in the number of CD11b+Gr1+F4/80- cells
• total cell number in the spleen in about 5-fold higher than in controls
• serum levels of interleukin-17A are increased
• splenocytes produce increased levels of interleukin-1 beta when stimulated with LPS
• cooling of the whole body at 4 degrees Celcius for 1 minute increases interleukin-1 beta levels in mutants but not controls
• exposure of footpads to cold results in increased thickness and exanthema-like color change, indicating increased inflammation in response to cold
• severe cell infiltration in the joints
• severe cell infiltration in the joints and erosion of the bone
• severe cell infiltration in the skin
• mice exhibit dermatitis starting at 3 weeks of age
• mice exposed to a cold stimulus exhibit increased inflammation and develop an urticarial-like dermatitis

homeostasis/metabolism
• serum levels of interleukin-17A are increased
• mice exhibit swollen joints starting at 3 weeks of age

hematopoietic system
• mice show increased numbers of CD11b+Gr1+ neutrophils
• most cells that produce Il17a are neutrophils
• mice how increased numbers of activated T cells
• spleen shows a 15-fold increase in the number of CD11b+Gr1+F4/80- cells
• total cell number in the spleen in about 5-fold higher than in controls

integument
• severe cell infiltration in the skin
• mice exposed to a cold stimulus exhibit increased inflammation and develop an urticarial-like dermatitis
• mice exhibit dermatitis starting at 3 weeks of age

skeleton
• mice exhibit swollen joints starting at 3 weeks of age
• severe cell infiltration in the joints
• severe cell infiltration in the joints and erosion of the bone

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
familial cold autoinflammatory syndrome 4 DOID:0090065 OMIM:616115
J:219652





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory