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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vcantm2Hwat
targeted mutation 2, Hideto Watanabe
MGI:5694701
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Vcantm2Hwat/Vcantm2Hwat B6.Cg-Vcantm2Hwat MGI:5694707
hm2
 		Vcantm2Hwat/Vcantm2Hwat involves: 129 * BALB/c * C57BL/6 MGI:5694708
hm3
 		Vcantm2Hwat/Vcantm2Hwat involves: 129 * C57BL/6 MGI:5694709


Genotype
MGI:5694707
hm1
Allelic
Composition		 Vcantm2Hwat/Vcantm2Hwat
Genetic
Background		 B6.Cg-Vcantm2Hwat
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vcantm2Hwat mutation (0 available); any Vcan mutation (164 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5694708
hm2
Allelic
Composition		 Vcantm2Hwat/Vcantm2Hwat
Genetic
Background		 involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vcantm2Hwat mutation (0 available); any Vcan mutation (164 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:225115 )
• all mice that are born die within 6 hours of birth

cardiovascular system
abnormal interventricular septum morphology ( J:225115 )
• interventricular septa about to fuse to the top of cardiac wall at E14.5
• nearly fused at P0
ventricular septal defect ( J:225115 )
• at E14.5 and P0
abnormal cardiovascular system physiology ( J:225115 )
• endocardial cell proliferation is increased at E12.5 compared with wild-type cells
• mesenchymal cells exhibit impaired cell migration compared with wild-type cells

growth/size/body
decreased fetal size ( J:225115 )
• surviving mice at E14.5

homeostasis/metabolism
cyanosis ( J:225115 )
• at birth




Genotype
MGI:5694709
hm3
Allelic
Composition		 Vcantm2Hwat/Vcantm2Hwat
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vcantm2Hwat mutation (0 available); any Vcan mutation (164 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory