Phenotypes associated with this allele

• Allele Symbol: Denr^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5637029
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Denr^tm1b(KOMP)Wtsi/Denr^tm1b(KOMP)Wtsi	C57BL/6N-Denr^tm1b(KOMP)Wtsi/Wtsi	MGI:5767629
ht2	Denr^tm1b(KOMP)Wtsi/Denr^+	C57BL/6N-Denr^tm1b(KOMP)Wtsi/Wtsi	MGI:5797474

Genotype
MGI:5767629

hm1

• Allelic Composition: Denr^{tm1b(KOMP)Wtsi}/Denr^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Denr^{tm1b(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0287_2_D07

Data Sources

IMPC Data for Denr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment

• biased differentiation (diploid/polyploid trophoblast)

abnormal trophoblast giant cell morphology ( J:261316 )

• abnormal trophoblast giant cell size and morphology

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:261316 )

• lethality at E9.5-E10.5

prenatal lethality prior to heart atrial septation ( J:211773 )

IMPC - WTSI

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

Genotype
MGI:5797474

ht2

• Allelic Composition: Denr^{tm1b(KOMP)Wtsi}/Denr⁺
• Genetic Background: C57BL/6N-Denr^{tm1b(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0287_2_D07

Data Sources

IMPC Data for Denr

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - WTSI