Phenotypes associated with this allele

• Allele Symbol: Sostdc1^tm2Snd
• Allele Name: targeted mutation 2, Scott Sunders
• Allele ID: MGI:5617945
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sostdc1^tm2Snd/Sostdc1^tm2Snd	involves: 129S/SvEv	MGI:5770371
cx2	Lrp5^tm1Kry/Lrp5^tm1Kry Sostdc1^tm2Snd/Sostdc1^tm2Snd	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ	MGI:5770375

Genotype
MGI:5770371

hm1

• Allelic Composition: Sostdc1^tm2Snd/Sostdc1^tm2Snd
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Genetic correction of Wise with Lrp5 during ossification

mortality/aging

preweaning lethality, incomplete penetrance ( J:216098 )

• most homozygotes are viable; however, litter sizes are often reduced and there is a frequent increase in the number of resorptions

skeleton

increased bone mineral density ( J:216098 )

• between 1.5 to 3.0 months of age, homozygotes show a significant increase in whole body bone mineral density (BMD) relative to wild-type controls

• however, by 4 months of age the increase in BMD normalizes and is restored to wild-type levels

• Background Sensitivity: transient increase in BMD is less severe on a 129/SvEv genetic background than on a C57BL/6 genetic background

abnormal bone mineralization ( J:216098 )

• increased mineralization of phalanges in both the fore- and hindlimbs, clearly evident in digits 4 and 5 and fully penetrant at P0

Genotype
MGI:5770375

cx2

• Allelic Composition: Lrp5^tm1Kry/Lrp5^tm1Kry; Sostdc1^tm2Snd/Sostdc1^tm2Snd
• Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Genetic correction of Wise with Lrp5 during ossification

skeleton

skeleton phenotype ( J:216098 )

N • at PO, mineralization of phalanges is restored to near wild-type levels or those seen in single Lrp5^tm1Kry homozygotes; clearly seen in hindlimb digits 4 and 5