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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sostdc1tm2Snd
targeted mutated 2, Scott Sunders
MGI:5617945
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sostdc1tm2Snd/Sostdc1tm2Snd involves: 129S/SvEv MGI:5770371
cx2
Lrp5tm1Kry/Lrp5tm1Kry
Sostdc1tm2Snd/Sostdc1tm2Snd
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ MGI:5770375


Genotype
MGI:5770371
hm1
Allelic
Composition
Sostdc1tm2Snd/Sostdc1tm2Snd
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sostdc1tm2Snd mutation (0 available); any Sostdc1 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Genetic correction of Wise with Lrp5 during ossification

mortality/aging
• most homozygotes are viable; however, litter sizes are often reduced and there is a frequent increase in the number of resorptions

skeleton
• between 1.5 to 3.0 months of age, homozygotes show a significant increase in whole body bone mineral density (BMD) relative to wild-type controls
• however, by 4 months of age the increase in BMD normalizes and is restored to wild-type levels
• Background Sensitivity: transient increase in BMD is less severe on a 129/SvEv genetic background than on a C57BL/6 genetic background
• increased mineralization of phalanges in both the fore- and hindlimbs, clearly evident in digits 4 and 5 and fully penetrant at P0




Genotype
MGI:5770375
cx2
Allelic
Composition
Lrp5tm1Kry/Lrp5tm1Kry
Sostdc1tm2Snd/Sostdc1tm2Snd
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm1Kry mutation (0 available); any Lrp5 mutation (49 available)
Sostdc1tm2Snd mutation (0 available); any Sostdc1 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Genetic correction of Wise with Lrp5 during ossification

skeleton
N
• at PO, mineralization of phalanges is restored to near wild-type levels or those seen in single Lrp5tm1Kry homozygotes; clearly seen in hindlimb digits 4 and 5





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last database update
03/19/2019
MGI 6.13
The Jackson Laboratory