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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atp2b1tm1b(KOMP)Wtsi
targeted mutation 1b, Wellcome Trust Sanger Institute
MGI:5605735
Summary 3 genotypes


Genotype
MGI:6377657
hm1
Allelic
Composition		 Atp2b1tm1b(KOMP)Wtsi/Atp2b1tm1b(KOMP)Wtsi
Genetic
Background		 B6N(Cg)-Atp2b1tm1b(KOMP)Wtsi/Tcp
Cell Lines EPD0797_1_C06
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b1tm1b(KOMP)Wtsi mutation (2 available); any Atp2b1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )
• early blastocysts are present at lower than expected Mendelian ratios at E3.5 (16% versus 25%); no embryos or excess resorption sites are observed at E7.5

embryo
absent primitive endoderm ( J:279207 )
• limited or no primitive endoderm (PrE) cells are observed after 3 days in culture
absent trophectoderm ( J:279207 )
• although blastocysts hatch from the zona pellucida and form outgrowths with apparent inner cell mass, limited or no trophectoderm is observed after 3 days in culture




Genotype
MGI:5756751
hm2
Allelic
Composition		 Atp2b1tm1b(KOMP)Wtsi/Atp2b1tm1b(KOMP)Wtsi
Genetic
Background		 C57BL/6N-Atp2b1tm1b(KOMP)Wtsi/Tcp
Cell Lines EPD0797_1_C06
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b1tm1b(KOMP)Wtsi mutation (2 available); any Atp2b1 mutation (65 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5756750
ht3
Allelic
Composition		 Atp2b1tm1b(KOMP)Wtsi/Atp2b1+
Genetic
Background		 C57BL/6N-Atp2b1tm1b(KOMP)Wtsi/Tcp
Cell Lines EPD0797_1_C06
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b1tm1b(KOMP)Wtsi mutation (2 available); any Atp2b1 mutation (65 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear

homeostasis/metabolism

integument
absent vibrissae ( J:211773 )
IMPC - UCD

reproductive system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory