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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm1(Sirt1)Ktm
targeted mutation 1, Tadahiro Kitamura
MGI:5586718
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+
Tg(Pomc1-cre)16Lowl/0
involves: 129 * C57BL/6J * FVB/N MGI:5586724
cn2
Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+
Tg(Agrp-cre)1Gsb/0
involves: 129 * C57BL/6J * FVB/N MGI:5586725


Genotype
MGI:5586724
cn1
Allelic
Composition
Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+
Tg(Pomc1-cre)16Lowl/0
Genetic
Background
involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Sirt1)Ktm mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Pomc1-cre)16Lowl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice exhibit normal hypothalamus-pituitary-adrenal and hypothalamus-pituitary-thyroid axes
• noradrenaline turnover in the white adipose tissue is increased in male mice compared to in control mice
• however, turnover in skeletal muscle is normal
• mice exhibit improved leptin sensitivity compared with control mice
• mice tend to be cold-resistant for short-term exposure compared with control mice
• however, mice fed a high fat high sugar diet exhibit normal cold resistance
• male mice fed normal chow exhibit increased energy expenditure suggested by a tend toward higher oxygen consumption and lower locomotor activity compared with control mice
• however, mice fed a high fat high sugar diet exhibit normal energy expenditure
• trend in male mice fed normal chow

growth/size/body
N
• male and female mice fed normal chow exhibit normal body length
• mice fed a high fat high sugar diet exhibit normal weight gain
• in male, but not female, mice fed normal chow

adipose tissue
• in male, but not female, mice fed normal chow
• however, mice fed a high fat high sugar diet exhibit normal adiposity
• in male mice fed normal chow
• noradrenaline turnover in the white adipose tissue is increased in male mice compared to in control mice
• however, turnover in skeletal muscle is normal

behavior/neurological
N
• female and male mice exhibit normal food intake
• trend in male mice fed normal chow
• however, mice fed a high fat high sugar diet exhibit normal locomotion




Genotype
MGI:5586725
cn2
Allelic
Composition
Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+
Tg(Agrp-cre)1Gsb/0
Genetic
Background
involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Sirt1)Ktm mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Agrp-cre)1Gsb mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• mice exhibit normal body length
• female and male mice fed a high fat high sugar diet exhibit normal body weight
• female mice exhibit a tend toward increased body weight
• in male mice fed normal chow

behavior/neurological
N
• mice fed normal chow or a high fat high sugar diet exhibit normal locomotor activity
• in male mice fed normal chow
• in female mice fed normal chow

homeostasis/metabolism
N
• mice fed normal chow exhibit normal energy expenditure, plasma T4 levels, fasting-induced lipolysis and rectal temperature
• mice fed a high fat high sugar diet exhibit normal energy expenditure and cold tolerance
• mice exhibit improved leptin sensitivity compared with control mice

adipose tissue
N
• mice fed normal chow or a high fat high sugar diet exhibit normal adiposity





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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory