All Phenotypes Piezo1<tm1b(KOMP)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Piezo1^{tm1b(KOMP)Wtsi}
targeted mutation 1b, Wellcome Trust Sanger Institute
MGI:5582446

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Piezo1^{tm1b(KOMP)Wtsi}/Piezo1^{tm1b(KOMP)Wtsi}	C57BL/6N-Piezo1^{tm1b(KOMP)Wtsi}/MbpMmucd	MGI:6325166
hm2	Piezo1^{tm1b(KOMP)Wtsi}/Piezo1^{tm1b(KOMP)Wtsi}	C57BL/6N-Piezo1^{tm1b(KOMP)Wtsi}/Ucd	MGI:5767759
ht3	Piezo1^{tm1b(KOMP)Wtsi}/Piezo1⁺	C57BL/6N-Piezo1^{tm1b(KOMP)Wtsi}/MbpMmucd	MGI:6325165
ht4	Piezo1^{tm1b(KOMP)Wtsi}/Piezo1⁺	C57BL/6N-Piezo1^{tm1b(KOMP)Wtsi}/Ucd	MGI:6263160

Allelic Composition	Piezo1^{tm1b(KOMP)Wtsi}/Piezo1^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Piezo1^{tm1b(KOMP)Wtsi}/MbpMmucd
Cell Lines	EPD0500_5_B12

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Piezo1^{tm1b(KOMP)Wtsi} mutation (1 available); any Piezo1 mutation (87 available)

Data Sources

IMPC Data for Piezo1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryonic growth retardation ( J:211773 )

IMPC - TCP

abnormal embryo size ( J:211773 )

IMPC - TCP

abnormal limb bud morphology ( J:211773 )

IMPC - TCP

abnormal placenta size ( J:211773 )

IMPC - TCP

pale yolk sac ( J:211773 )

IMPC - TCP

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - TCP

abnormal embryo size ( J:211773 )

IMPC - TCP

integument

pallor ( J:211773 )

IMPC - TCP

limbs/digits/tail

abnormal limb bud morphology ( J:211773 )

IMPC - TCP

Allelic Composition	Piezo1^{tm1b(KOMP)Wtsi}/Piezo1^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Piezo1^{tm1b(KOMP)Wtsi}/Ucd
Cell Lines	EPD0500_5_B12

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Piezo1^{tm1b(KOMP)Wtsi} mutation (1 available); any Piezo1 mutation (87 available)

Data Sources

IMPC Data for Piezo1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

Allelic Composition	Piezo1^{tm1b(KOMP)Wtsi}/Piezo1⁺
Genetic Background	C57BL/6N-Piezo1^{tm1b(KOMP)Wtsi}/MbpMmucd
Cell Lines	EPD0500_5_B12

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Piezo1^{tm1b(KOMP)Wtsi} mutation (1 available); any Piezo1 mutation (87 available)

Data Sources

IMPC Data for Piezo1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo size ( J:211773 )

IMPC - TCP

abnormal placenta size ( J:211773 )

IMPC - TCP

growth/size/body

abnormal embryo size ( J:211773 )

IMPC - TCP

Allelic Composition	Piezo1^{tm1b(KOMP)Wtsi}/Piezo1⁺
Genetic Background	C57BL/6N-Piezo1^{tm1b(KOMP)Wtsi}/Ucd
Cell Lines	EPD0500_5_B12

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Piezo1^{tm1b(KOMP)Wtsi} mutation (1 available); any Piezo1 mutation (87 available)

Data Sources

IMPC Data for Piezo1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased locomotor activity ( J:211773 )

IMPC - UCD

homeostasis/metabolism

increased circulating alanine transaminase level ( J:211773 )

IMPC - UCD

renal/urinary system

abnormal urinary bladder morphology ( J:211773 )

IMPC - UCD

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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