Phenotypes associated with this allele

• Allele Symbol: Lamb2^npht
• Allele Name: nephertiti
• Allele ID: MGI:5578541
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lamb2^npht/Lamb2^npht	involves: C57BL/6	MGI:5578543

Genotype
MGI:5578543

hm1

• Allelic Composition: Lamb2^npht/Lamb2^npht
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased urine protein level ( J:208069 )

abnormal kidney morphology ( J:208069 )

• mice exhibit a nephrotic phenotype

increased renal glomerulus basement membrane thickness ( J:208069 )

• with widespread basement membrane spikes

abnormal renal tubule epithelium morphology ( J:208069 )

• protein casts within tubules and protein resorption droplets within tubular epithelium

abnormal kidney physiology ( J:208069 )

• mice exhibit a nephrotic phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:208069 )

• between 17 and 25 weeks

increased circulating triglyceride level ( J:208069 )

• between 17 and 25 weeks

decreased circulating serum albumin level ( J:208069 )

• between 17 and 25 weeks

decreased circulating total protein level ( J:208069 )

• between 17 and 25 weeks

increased urine protein level ( J:208069 )

growth/size/body

decreased body weight ( J:208069 )

• between 17 and 25 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Pierson syndrome		DOID:0060852	OMIM:609049	J:208069