Phenotypes associated with this allele

• Allele Symbol: Piezo2^tm2.2Apat
• Allele Name: targeted mutation 2.2, Ardem Patapoutian
• Allele ID: MGI:5574479
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Atoh1^tm4.1Hzo/Atoh1^+ Piezo2^tm2.2Apat/Piezo2^tm2.2Apat Tg(KRT14-cre)1Amc/0	involves: 129S7/SvEvBrd * C57BL/6 * CBA	MGI:5577087

Genotype
MGI:5577087

cn1

• Allelic Composition: Atoh1^tm4.1Hzo/Atoh1⁺; Piezo2^tm2.2Apat/Piezo2^tm2.2Apat; Tg(KRT14-cre)1Amc/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal mechanical nociception ( J:211312 )

• upon mechanical stimulation of Merkel cells, mutant cells do not display mechanically-activated currents but wild-type cells show a robust response

• sustained depolarization seen in wild-type cells upon injection of current is absent in Piezo2-deficient Merkel cells

• in an automated von Frey filament test, mutants show decreased percent withdrawal responses at lower forces only with similar responses at higher forces

nervous system

abnormal nervous system electrophysiology ( J:211312 )

• firing frequencies of slowly adapting ABeta fibers at various frequencies are reduced, and conduction velocities is reduced in ex vivo skin-saphenous nerve ending recordings

• touch dome afferents display short reduced firing compare to wild-type cells; firing patterns are intermediately adapting compared to maintained firing of wild-type touch dome afferents such that spikes fired and overall firing rates are significantly reduced