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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Piezo2tm2.2Apat
targeted mutation 2.2, Ardem Patapoutian
MGI:5574479
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Atoh1tm4.1Hzo/Atoh1+
Piezo2tm2.2Apat/Piezo2tm2.2Apat
Tg(KRT14-cre)1Amc/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA MGI:5577087


Genotype
MGI:5577087
cn1
Allelic
Composition
Atoh1tm4.1Hzo/Atoh1+
Piezo2tm2.2Apat/Piezo2tm2.2Apat
Tg(KRT14-cre)1Amc/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh1tm4.1Hzo mutation (1 available); any Atoh1 mutation (21 available)
Piezo2tm2.2Apat mutation (1 available); any Piezo2 mutation (5 available)
Tg(KRT14-cre)1Amc mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• upon mechanical stimulation of Merkel cells, mutant cells do not display mechanically-activated currents but wild-type cells show a robust response
• sustained depolarization seen in wild-type cells upon injection of current is absent in Piezo2-deficient Merkel cells
• in an automated von Frey filament test, mutants show decreased percent withdrawal responses at lower forces only with similar responses at higher forces

nervous system
• firing frequencies of slowly adapting ABeta fibers at various frequencies are reduced, and conduction velocities is reduced in ex vivo skin-saphenous nerve ending recordings
• touch dome afferents display short reduced firing compare to wild-type cells; firing patterns are intermediately adapting compared to maintained firing of wild-type touch dome afferents such that spikes fired and overall firing rates are significantly reduced

integument
• upon mechanical stimulation of Merkel cells, mutant cells do not display mechanically-activated currents but wild-type cells show a robust response
• sustained depolarization seen in wild-type cells upon injection of current is absent in Piezo2-deficient Merkel cells
• in an automated von Frey filament test, mutants show decreased percent withdrawal responses at lower forces only with similar responses at higher forces





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory