Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5tm1.2Cogr mutation
(2 available);
any
Cdkl5 mutation
(19 available)
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Hind-limb clasping in Cdkl5tm1.2Cogr/Cdkl5tm1.2Cogr mice
behavior/neurological
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• in the home cage
• however, activity in a novel open arena is normal
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• longer mean duration of high-amplitude bursts and lower frequency as detected by electroencephalographic (EEG) recordings
• however, mice exhibit normal spontaneous and induced seizure occurrences
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• mice treated with kainic acid fail to exhibit an increase in dose-dependent low frequency EEG power unlike wild-type mice
• however, mice exhibit normal spontaneous and induced seizure occurrences
|
nervous system
|
• longer mean duration of high-amplitude bursts and lower frequency as detected by electroencephalographic (EEG) recordings
• however, mice exhibit normal spontaneous and induced seizure occurrences
|
|
• mice treated with kainic acid fail to exhibit an increase in dose-dependent low frequency EEG power unlike wild-type mice
• however, mice exhibit normal spontaneous and induced seizure occurrences
|
vision/eye
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• decreased amplitude, but not latency, of the first positive wave
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Allelic Composition |
Cdkl5tm1.2Cogr/Cdkl5+
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Genetic Background |
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5tm1.2Cogr mutation
(2 available);
any
Cdkl5 mutation
(19 available)
|
|
|
behavior/neurological
|
• intermediate in the home cage
• however, activity in a novel open arena is normal
|
vision/eye
|
• decreased amplitude, but not latency, of the first positive wave
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5tm1.2Cogr mutation
(2 available);
any
Cdkl5 mutation
(19 available)
Tg(Thy1-YFP)#Jrs mutation
(0 available)
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nervous system
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• reduced total length of apical dendritic arbors of cortical and hippocampal pyramidal neurons
• reduced branching of pyramidal neuron dendrites
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5tm1.2Cogr mutation
(2 available);
any
Cdkl5 mutation
(19 available)
Tg(Thy1-YFP)#Jrs mutation
(0 available)
|
|
|
nervous system
|
• reduced total length of apical dendritic arbors of cortical and hippocampal pyramidal neurons
• reduced branching of pyramidal neuron dendrites
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5tm1.2Cogr mutation
(2 available);
any
Cdkl5 mutation
(19 available)
Tg(Thy1-YFP)#Jrs mutation
(0 available)
|
|
|
nervous system
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• intermediate reduction in total length of apical dendritic arbors of cortical and hippocampal pyramidal neurons with bimodal distribution
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Allelic Composition |
Cdkl5tm1.2Cogr/Y
|
|
Genetic Background |
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5tm1.2Cogr mutation
(2 available);
any
Cdkl5 mutation
(19 available)
|
|
|
behavior/neurological
|
• in the home cage
• however, activity in a novel open arena is normal
|
|
• longer mean duration of high-amplitude bursts and lower frequency as detected by electroencephalographic (EEG) recordings
• however, mice exhibit normal spontaneous and induced seizure occurrences
|
|
• mice treated with kainic acid fail to exhibit an increase in dose-dependent low frequency EEG power unlike wild-type mice
• however, mice exhibit normal spontaneous and induced seizure occurrences
|
nervous system
|
• longer mean duration of high-amplitude bursts and lower frequency as detected by electroencephalographic (EEG) recordings
• however, mice exhibit normal spontaneous and induced seizure occurrences
|
|
• mice treated with kainic acid fail to exhibit an increase in dose-dependent low frequency EEG power unlike wild-type mice
• however, mice exhibit normal spontaneous and induced seizure occurrences
|
vision/eye
|
• decreased amplitude, but not latency, of the first positive wave
|