Phenotypes associated with this allele

• Allele Symbol: Xylt1^npo
• Allele Name: napoleon
• Allele ID: MGI:5563785
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Xylt1^npo/Xylt1^npo	involves: C57BL/6J * FVB/NJ	MGI:5565182

Genotype
MGI:5565182

hm1

• Allelic Composition: Xylt1^npo/Xylt1^npo
• Genetic Background: involves: C57BL/6J * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:205339 )

• fewer than expected mice are present at weaning

skeleton

skeleton phenotype ( J:205339 )

N • chondrocyte proliferation is normal

N • cortical bones exhibit normal morphology

short mandible ( J:205339 )

• at E16.5

short humerus ( J:205339 )

• at E14.5, E16.5 and E18.5

• in adult mice

short ulna ( J:205339 )

• in adult mice

• at E14.5, E16.5 and E18.5

decreased width of hypertrophic chondrocyte zone ( J:205339 )

short ribs ( J:205339 )

• short and thick

small thoracic cage ( J:205339 )

• in adult mice

abnormal bone structure ( J:205339 )

• decreased radius of the endosteal and periosteal radius

abnormal osteoclast differentiation ( J:205339 )

• more rapidly maturing chondrocytes compared with wild-type mice

increased trabecular bone volume ( J:205339 )

abnormal periosteum morphology ( J:205339 )

• decreased radius

decreased bone trabecula number ( J:205339 )

• with increased spacing

increased trabecular bone connectivity density ( J:205339 )

increased trabecular bone thickness ( J:205339 )

decreased chondrocyte number ( J:205339 )

• in prehypertrophic and hypertrophic domains

abnormal endochondral bone ossification ( J:205339 )

• suggested by reduced skeletal element length

premature bone ossification ( J:205339 )

• of the talus at E18.5 and cervical vertebrae at E16.5

growth/size/body

growth/size/body region phenotype ( J:205339 )

N • crown to rump length at E16.5 is normal

short snout ( J:205339 )

decreased body size ( J:205339 )

disproportionate dwarf ( J:205339 )

craniofacial

short mandible ( J:205339 )

• at E16.5

short snout ( J:205339 )

cellular

abnormal osteoclast differentiation ( J:205339 )

• more rapidly maturing chondrocytes compared with wild-type mice

immune system

abnormal osteoclast differentiation ( J:205339 )

• more rapidly maturing chondrocytes compared with wild-type mice

limbs/digits/tail

abnormal forelimb stylopod morphology ( J:205339 )

• short at E14.5 and E16.5

short humerus ( J:205339 )

• at E14.5, E16.5 and E18.5

• in adult mice

abnormal forelimb zeugopod morphology ( J:205339 )

• short at E14.5 and E16.5

short ulna ( J:205339 )

• at E14.5, E16.5 and E18.5

• in adult mice

abnormal hindlimb stylopod morphology ( J:205339 )

• short at E14.5 and E16.5

abnormal hindlimb zeugopod morphology ( J:205339 )

• short at E14.5 and E16.5

rhizomelic limb ( J:205339 )

• at E18.5 and worse in adulthood

• rhizomelic shortening in adult mice

hematopoietic system

abnormal osteoclast differentiation ( J:205339 )

• more rapidly maturing chondrocytes compared with wild-type mice