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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Akt1tm1Zzy
targeted mutation 1, Zhongzhou Yang
MGI:5563541
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Akt1tm1Zzy/Akt1tm1Zzy
Akt3tm1Hem/Akt3tm1Hem
Tg(Myhc-cre)1Xya/0
involves: 129P2/OlaHsd * FVB MGI:5563578


Genotype
MGI:5563578
cn1
Allelic
Composition
Akt1tm1Zzy/Akt1tm1Zzy
Akt3tm1Hem/Akt3tm1Hem
Tg(Myhc-cre)1Xya/0
Genetic
Background
involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1tm1Zzy mutation (0 available); any Akt1 mutation (24 available)
Akt3tm1Hem mutation (0 available); any Akt3 mutation (8 available)
Tg(Myhc-cre)1Xya mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• following myocardial infarction, rapamycin-treated mice exhibit reduced heart weight compared with untreated mice
• however, rapamycin treatment following myocardial infarction fail to exhibit a change in fibrotic index, ejection fraction, fractional shortening or left ventricular internal diameter at end-diastole

cardiovascular system
• following myocardial infarction, rapamycin-treated mice exhibit reduced heart weight compared with untreated mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory