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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cpeb3tm1.2Yshu
targeted mutation 1.2, Yi-Shuian Huang
MGI:5562642
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cpeb3tm1.2Yshu/Cpeb3tm1.2Yshu involves: 129S4/SvJae * C57BL/6 MGI:5562644


Genotype
MGI:5562644
hm1
Allelic
Composition
Cpeb3tm1.2Yshu/Cpeb3tm1.2Yshu
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpeb3tm1.2Yshu mutation (0 available); any Cpeb3 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• severely reduced

growth/size/body
N
• normal body weight

homeostasis/metabolism
• increase in Grin1-induced calcium influx in cultured neurons

vision/eye
N
• normal visual acuity

behavior/neurological
N
• normal motor coordination on the rotarod, locomotor abilities, spatial learning, and swimming ability
• more rapid acquisition but slower extinction
• better consolidated spatial memory in a Morris water maze
• in open field but not in elevated plus maze
• locomoter activity is significantly lower in the open field

nervous system
N
• normal paired-pulse facilitation in adult hippocampal slices
• normal long term potentiation and long term depression in 9- to 12-week-old adult hippocampal slices
• enlarge spine head at E18 with normal dendritic arborization
• width of the spine heads of pyramidal excitatory neurons is enlarged at E18
• increase in Grin1-induced calcium influx in cultured neurons
• paired-pulse low frequency stimulation induced LTD is enhanced in young (3-4 weeks of age) but not adult hippocampal slices





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory