Phenotypes associated with this allele

• Allele Symbol: Ifngr1^tm1.2Rds
• Allele Name: targeted mutation 1.2, Robert D Schreiber
• Allele ID: MGI:5558049
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ifngr1^tm1.2Rds/Ifngr1^tm1.2Rds	C57BL/6NTac-Ifngr1^tm1.2Rds	MGI:5558058

Genotype
MGI:5558058

hm1

• Allelic Composition: Ifngr1^tm1.2Rds/Ifngr1^tm1.2Rds
• Genetic Background: C57BL/6NTac-Ifngr1^tm1.2Rds

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:206257 )

• in mice infected with L. monocytogenes

immune system

decreased interleukin-12b secretion ( J:206257 )

• abrogation of production from CD8a+ dendritic cells of mice infected with L. monocytogenes

increased susceptibility to bacterial infection ( J:206257 )

• mice infected with L. monocytogenes exhibit increased mortality, spleen and liver bacterial counts and abrogation of IL12b production from CD8a+ dendritic cells compared with wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:206257 )

• in mice infected with L. monocytogenes