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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfrsf21tm1Arte
targeted mutation 1, TaconicArtemis
MGI:5546637
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnfrsf21tm1Arte/Tnfrsf21tm1Arte involves: C57BL/6NTac MGI:5547355


Genotype
MGI:5547355
hm1
Allelic
Composition		 Tnfrsf21tm1Arte/Tnfrsf21tm1Arte
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf21tm1Arte mutation (0 available); any Tnfrsf21 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal oligodendrocyte apoptosis ( J:205651 )
• reduced number of apoptotic oligodendrocytes from cultured oligodendrocyte progenitor cells in differentiation medium compared with cultured wild-type cells
increased oligodendrocyte number ( J:205651 )
• 2.5-fold more oligodendrocytes with fewer apoptotic oligodendrocytes from cultured oligodendrocyte progenitor cells in differentiation medium compared with cultured wild-type cells
abnormal myelination ( J:205651 )
• early-onset myelination during development

cellular
abnormal oligodendrocyte apoptosis ( J:205651 )
• reduced number of apoptotic oligodendrocytes from cultured oligodendrocyte progenitor cells in differentiation medium compared with cultured wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory