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Allele Symbol Allele Name Allele ID |
Chst14tm1.1Msch targeted mutation 1.1, Melitta Schachner MGI:5528395 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some mice die between E16.5 and E18.5
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• some mice die within a few days after birth
• however, viable mice exhibit normal life span
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• no offspring are produced from breeding homozygotes
• Background Sensitivity: viability of offspring is improved by greater 129 contribution to the background compared with mice with a greater C57BL/6 contribution to the background
• however, homozygotes bred to wild-type mice produce offspring
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 N |
• 8 week old male mice exhibit normal brain weight and normal appearance of the neocortex, hippocampus and cerebellum
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• in primary cultures, Schwann cells isolated from dorsal root and nerves exhibit 2 times longer cell processes compared with wild-type cells
• longer processes in cultured motor neurons from E14.5 spinal cords
• 3 times longer neurites from cultured P7 cerebella neurons
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• in primary cultures of Schwann cells from dorsal root and nerves
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• in primary cultures, Schwann cells isolated from dorsal root and nerves exhibit 2 times longer cell processes compared with wild-type cells
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• in primary cultures, Schwann cells isolated from dorsal root and nerves exhibit 2 times longer cell processes compared with wild-type cells
• longer processes in cultured motor neurons from E14.5 spinal cords
• 3 times longer neurites from cultured P7 cerebella neurons
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• Background Sensitivity: increased tooth growth in mice with a greater C57BL/6 contribution to the background compared with mice with a greater 129 contribution to the background
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• in some mice
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• between 6 and 52 weeks
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• decreased weight in 8 week old male mice
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• Background Sensitivity: more severe in mice with a greater C57BL/6 contribution to the background compared with mice with a greater 129 contribution to the background
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• in 8 week old male mice
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• in 8 week old male mice
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• in 8 week old male mice
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• Background Sensitivity: increased tooth growth in mice with a greater C57BL/6 contribution to the background compared with mice with a greater 129 contribution to the background
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• after femoral nerve injury, mice exhibit accelerated functional recovery and accelerated axonal regeneration compared with wild-type mice
• however, injured mice exhibit normal motor innervation pattern, remyelination and cell proliferation
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• skin fragility at 4 to 6 months
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• in primary cultures, Schwann cells isolated from dorsal root and nerves exhibit 2 times longer cell processes compared with wild-type cells
• longer processes in cultured motor neurons from E14.5 spinal cords
• 3 times longer neurites from cultured P7 cerebella neurons
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• in primary cultures of Schwann cells from dorsal root and nerves
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• Background Sensitivity: increased tooth growth in mice with a greater C57BL/6 contribution to the background compared with mice with a greater 129 contribution to the background
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• decreased weight in 8 week old male mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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