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Allele Symbol Allele Name Allele ID |
Flt1tm1.1Fong targeted mutation 1.1, Guo-Hua Fong MGI:5523702 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the brain and liver of tamoxifen treated mice compared with control mice but not as severe as in mice also lacking the Kdr null allele
• some small focal areas in the retina in tamoxifen-treated mice relative to mice lacking the Kdr null allele
• however, angiogenesis in the heart is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• with increased surface area and branching points in the retinal inner plexiform layer of mice treated with tamoxifen from P1 to P4
• in the retinal tissue between the inner plexiform layer and ganglion cell layer of mice treated with tamoxifen from P1 to P4
• in the retinal inner and outer plexiform layer, lung, heart, brain, kidney, liver and cornea of mice treated with tamoxifen as adults
• after left anterior descending coronary artery ligation in tamoxifen-treated mice
• the retina of neonates treated with tamoxifen exhibit increased tip cells by P5 compared with control mice
• however, tamoxifen-treated mice exhibit normal vascular maturation and perfusion
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• 8 weeks after left anterior descending coronary artery ligation, tamoxifen-treated mice exhibit decreased infarct area and increase in PECAM-1 positive vessels in infarcted and non-infarcted areas compared with control mice
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• in tamoxifen treated mice exposed to high concentration of VEGF-A
• however, permeability is normal without VEGF-A treatment or with the addition of SU1498 (anti-VEGF-A inhibitor)
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• in the retina (ganglion cell layer and inner and outer plexiform layer) of tamoxifen-treated mice at P21
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• at P21 in mice treated with tamoxifen as neonates
• however, mice treated with tamoxifen as adults are not visibly different from wild-type mice
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• at P21 in the liver of tamoxifen-treated mice
• however, tamoxifen-treated mice subjected to left anterior descending coronary artery ligation exhibit normal macrophage numbers in the infarcted myocardium
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• 8 weeks after left anterior descending coronary artery ligation, tamoxifen-treated mice exhibit decreased infarct area and increase in PECAM-1 positive vessels in infarcted and non-infarcted areas compared with control mice
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• at P21 in the liver of tamoxifen-treated mice
• however, tamoxifen-treated mice subjected to left anterior descending coronary artery ligation exhibit normal macrophage numbers in the infarcted myocardium
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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