Phenotypes associated with this allele

• Allele Symbol: Prkci^tm1.1Rfar
• Allele Name: targeted mutation 1.1, Robert V Farese Sr
• Allele ID: MGI:5520927
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkci^tm1.1Rfar/Prkci^tm1.1Rfar	involves: 129P2/OlaHsd * BALB/cJ * NMRI	MGI:5520953

Genotype
MGI:5520953

hm1

• Allelic Composition: Prkci^tm1.1Rfar/Prkci^tm1.1Rfar
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal development of Prkci^tm1.1Rfar/Prkci^tm1.1Rfar embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:202124 )

• mice are reabsorbed by E10.5

embryo

abnormal mesoderm development ( J:202124 )

• despite normal initiation, mesoderm formation halts prematurely compared to in wild-type mice

abnormal proximal-distal axis patterning ( J:202124 )

• at E7.5, embryos are compressed along the proximal-distal axis with small amniotic cavity compared with wild-type mice

abnormal rostral-caudal axis patterning ( J:202124 )

• lacking polarity at E8.5

embryonic growth retardation ( J:202124 )

• at E8.5

thick embryonic epiblast ( J:202124 )

abnormal head fold morphology ( J:202124 )

• reduced or absent at E8.5

absent somites ( J:202124 )

• at E8.5

absent allantois ( J:202124 )

• reduced or absent at E8.5

small allantois ( J:202124 )

• reduced or absent at E8.5

small amniotic cavity ( J:202124 )

cardiovascular system

abnormal heart tube morphology ( J:202124 )

• reduced or absent at E8.5

absent heart tube ( J:202124 )

• reduced or absent at E8.5

growth/size/body

embryonic growth retardation ( J:202124 )

• at E8.5

cellular

abnormal cell morphology ( J:202124 )

• changes in the integrity of cell-cell contacts in embryos