Phenotypes associated with this allele

• Allele Symbol: Cavin3^tm1Pemi
• Allele Name: targeted mutation 1, Peter Michaely
• Allele ID: MGI:5518819
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cavin3^tm1Pemi/Cavin3^tm1Pemi	B6.129S4-Cavin3^tm1Pemi	MGI:5518824

Genotype
MGI:5518824

hm1

• Allelic Composition: Cavin3^tm1Pemi/Cavin3^tm1Pemi
• Genetic Background: B6.129S4-Cavin3^tm1Pemi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cellular respiration ( J:202374 )

• increased fermentative glycolysis observed in lung tissue (Warburg metabolism)

• lung tissue from 6 week old mice has increased glucose consumption and increased lactate production

adipose tissue

lipodystrophy ( J:202374 )

• severe lipdystrophy as compared to wild type

growth/size/body

decreased body weight ( J:202374 )

• 40% reduction in body mass by 24 months as compared to wild type

cachexia ( J:202374 )

liver/biliary system

hepatic steatosis ( J:202374 )

• areas of steatosis observed in liver

mortality/aging

premature death ( J:202374 )

• 40% of mice die by 24 months of age

• death is the result of cachexia