Phenotypes associated with this allele

• Allele Symbol: Rhcg^tm1Tigm
• Allele Name: targeted mutation 1, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:5496356
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rhcg^tm1Tigm/Rhcg^tm1Tigm	involves: 129S/SvEvBrd * C57BL/6	MGI:5496369
ht2	Rhcg^tm1Tigm/Rhcg^+	involves: 129S/SvEvBrd * C57BL/6	MGI:5496368

Genotype
MGI:5496369

hm1

• Allelic Composition: Rhcg^tm1Tigm/Rhcg^tm1Tigm
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:196009 )

• while on short or long term acid load

renal/urinary system

decreased urine ammonia level ( J:196009 )

• while on long term acid load

abnormal kidney collecting duct morphology ( J:196009 )

• mice fed a 2-day HCl diet exhibit total, apical and basolateral membrane permeabilities for ammonium are reduced compared with wild-type mice

abnormal kidney medulla morphology ( J:196009 )

• accumulates ammonium in mice fed an HCl diet for 4 days

homeostasis/metabolism

decreased urine ammonia level ( J:196009 )

• while on long term acid load

acidosis ( J:196009 )

• very severe acidosis while on short and long term acid load

Genotype
MGI:5496368

ht2

• Allelic Composition: Rhcg^tm1Tigm/Rhcg⁺
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6

renal/urinary system

increased urine pH ( J:196009 )

• while on long term acid load

abnormal kidney collecting duct morphology ( J:196009 )

• mice fed a 2-day HCl diet exhibit total and apical membrane permeabilities for ammonium are reduced compared with wild-type mice

• however, basolateral membrane ammonium permeability is normal

homeostasis/metabolism

acidosis ( J:196009 )

• while on long term acid load

increased urine pH ( J:196009 )

• while on long term acid load