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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atxn3tm1Hlp
targeted mutation 1, Henry L Paulson
MGI:5493478
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Atxn3tm1Hlp/Atxn3tm1Hlp involves: C57BL/6 MGI:5493481
ht2
Atxn3tm1Hlp/Atxn3+ involves: C57BL/6 MGI:5688780


Genotype
MGI:5493481
hm1
Allelic
Composition
Atxn3tm1Hlp/Atxn3tm1Hlp
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atxn3tm1Hlp mutation (1 available); any Atxn3 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit widespread intranuclear accumulation of the mutant Atxn23 protein in the brain




Genotype
MGI:5688780
ht2
Allelic
Composition
Atxn3tm1Hlp/Atxn3+
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atxn3tm1Hlp mutation (1 available); any Atxn3 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• ubiquitin-positive extranuclear neuronal aggregates in the brain, especially in the stratum radiatum of the hippocampus, the subiculum, central amygdala and bed nucleus of the stria terminalis that are localized to neuritic processes
• extranuclear inclusions are seen as small puncta in the hippocampal neuropil at 3 months of age and grow over time into large, irregular structures by 1 year of age
• mice exhibit intranuclear accumulation of the mutant Atxn3 protein in the brain by 10 weeks of age and abundant nuclear inclusions
• however, degenerative changes in the brain are not seen

behavior/neurological
N
• mice exhibit normal fear conditioning to shock





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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory