Analysis Tools
nervous system
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• mice exhibit widespread intranuclear accumulation of the mutant Atxn23 protein in the brain
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Allele Symbol Allele Name Allele ID |
Atxn3tm1Hlp targeted mutation 1, Henry L Paulson MGI:5493478 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit widespread intranuclear accumulation of the mutant Atxn23 protein in the brain
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• ubiquitin-positive extranuclear neuronal aggregates in the brain, especially in the stratum radiatum of the hippocampus, the subiculum, central amygdala and bed nucleus of the stria terminalis that are localized to neuritic processes
• extranuclear inclusions are seen as small puncta in the hippocampal neuropil at 3 months of age and grow over time into large, irregular structures by 1 year of age
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• mice exhibit intranuclear accumulation of the mutant Atxn3 protein in the brain by 10 weeks of age and abundant nuclear inclusions
• however, degenerative changes in the brain are not seen
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| N |
• mice exhibit normal fear conditioning to shock
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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