About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mlanatm1.2Bee
targeted mutation 1.2, Friedrich Beermann
MGI:5476663
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mlanatm1.2Bee/Mlanatm1.2Bee involves: 129S/SvEv * C57BL/6 * FVB/N * SJL MGI:5484926
cx2
 		Mlanatm1.2Bee/Mlanatm1.2Bee
Tyrc/Tyrc 		involves: 129S/SvEv * C57BL/6 * FVB/N * SJL MGI:5484927


Genotype
MGI:5484926
hm1
Allelic
Composition		 Mlanatm1.2Bee/Mlanatm1.2Bee
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlanatm1.2Bee mutation (1 available); any Mlana mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:194886 )
N
• mice exhibit normal tail skin, footpad and retina pigmentation
abnormal hair follicle melanocyte morphology ( J:194886 )
• hair follicle melanosomes have reduced melanin and eumelanin content compared with melanosomes from wild-type mice
• melanosomes in hair follicles exhibit blebbing of the limiting membrane with vesicles between the pigmented compartment and the limiting membrane unlike melanosomes from wild-type mice
diluted coat color ( J:194886 )
• visible 5 days after birth

integument
abnormal coat/ hair morphology ( J:194886 )
• reduced number of hairs
abnormal hair follicle melanocyte morphology ( J:194886 )
• hair follicle melanosomes have reduced melanin and eumelanin content compared with melanosomes from wild-type mice
• melanosomes in hair follicles exhibit blebbing of the limiting membrane with vesicles between the pigmented compartment and the limiting membrane unlike melanosomes from wild-type mice
diluted coat color ( J:194886 )
• visible 5 days after birth




Genotype
MGI:5484927
cx2
Allelic
Composition		 Mlanatm1.2Bee/Mlanatm1.2Bee
Tyrc/Tyrc
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlanatm1.2Bee mutation (1 available); any Mlana mutation (9 available)
Tyrc mutation (79 available); any Tyr mutation (375 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal hair follicle melanocyte morphology ( J:194886 )
• hair follicles lack stage III and IV melanosomes
• however, stage I and II melanosomes are normal

integument
abnormal hair follicle melanocyte morphology ( J:194886 )
• hair follicles lack stage III and IV melanosomes
• however, stage I and II melanosomes are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory