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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Casp4tm1.1Vmd
targeted mutation 1.1, Vishva M Dixit
MGI:5468949
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Casp4tm1.1Vmd/Casp4tm1.1Vmd involves: C57BL/6 MGI:5468970


Genotype
MGI:5468970
hm1
Allelic
Composition
Casp4tm1.1Vmd/Casp4tm1.1Vmd
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp4tm1.1Vmd mutation (0 available); any Casp4 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• in response to LPS challenge in a model of acute septic shock

immune system
• impaired cell death in response to CTB, E. coli, C. rodentium and V. cholerae
• however, bone marrow-derived macrophages stimulated with ATP of C. difficile toxin B exhibit normal cell death
• in response to LPS challenge in a model of acute septic shock
• in response to LPS challenge in a model of acute septic shock
• in response to LPS challenge in a model of acute septic shock
• from LPS-primed bone marrow-derived macrophage in response to CTB and E. coli
• from LPS-primed bone marrow-derived macrophages in response to cholera toxin B (CTB), E. coli, C. rodentium or V. cholera (with or without LPS priming)
• however, secretion in response to poly(dA:dT) double-stranded DNA, Francisella tularensis, flagellin, Pseudomonas aeruginosa adenylcyclase (AC) toxin14, listeriolysin O (LLO) toxin15, Clostridium difficile toxin B, monosodium urate (MSU), calcium pyrophosphate (CPPD)2,22 or the ionophore nigericin is normal
• mice are resistant to LPS challenge in a model of acute septic shock with reduced mortality and serum levels of IL1b, IL1a and IL18

cellular
• impaired cell death in response to CTB, E. coli, C. rodentium and V. cholerae
• however, bone marrow-derived macrophages stimulated with ATP of C. difficile toxin B exhibit normal cell death

homeostasis/metabolism
• in response to LPS challenge in a model of acute septic shock
• in response to LPS challenge in a model of acute septic shock
• in response to LPS challenge in a model of acute septic shock
• in response to LPS challenge in a model of acute septic shock

hematopoietic system
• impaired cell death in response to CTB, E. coli, C. rodentium and V. cholerae
• however, bone marrow-derived macrophages stimulated with ATP of C. difficile toxin B exhibit normal cell death





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/05/2021
MGI 6.17
The Jackson Laboratory