All Phenotypes Sp7<tm1Rnis> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sp7^tm1Rnis
targeted mutation 1, Riko Nishimura
MGI:5466595

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sp7^tm1Rnis/Sp7^tm1Rnis Tg(Col11a2-cre)1Ntsu/0	involves: C57BL * C57BL/6 * CBA/JNCrlj * DBA/2	MGI:5466671
cn2	Sp7^tm1Rnis/Sp7^tm1Rnis Tg(Col2a1-cre)1Bhr/0	involves: C57BL * C57BL/6 * CBA/JNCrlj * SJL	MGI:5466672
cn3	Sp7^tm1Rnis/Sp7^tm1Rnis Tg(Prrx1-cre)1Cjt/0	involves: C57BL * C57BL/6 * CBA/JNCrlj * SJL/J	MGI:5466673

Allelic Composition	Sp7^tm1Rnis/Sp7^tm1Rnis Tg(Col11a2-cre)1Ntsu/0
Genetic Background	involves: C57BL * C57BL/6 * CBA/JNCrlj * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sp7^tm1Rnis mutation (1 available); any Sp7 mutation (21 available)
Tg(Col11a2-cre)1Ntsu mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Impairment of ossification in various conditional Sp7^tm1Rnis/Sp7^tm1Rnis mice

skeleton

failure of endochondral bone ossification ( J:191589 )

• endochondral ossification stopped at the hypertrophic stage

Allelic Composition	Sp7^tm1Rnis/Sp7^tm1Rnis Tg(Col2a1-cre)1Bhr/0
Genetic Background	involves: C57BL * C57BL/6 * CBA/JNCrlj * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sp7^tm1Rnis mutation (1 available); any Sp7 mutation (21 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Impairment of ossification in various conditional Sp7^tm1Rnis/Sp7^tm1Rnis mice

skeleton

abnormal skeleton development ( J:191589 )

• mice exhibit reduced vascular invasion into cartilage because of insufficient space in non-degraded cartilage tissues indicating disruption in cartilage matric degradation compared to in control mice

• however, mice exhibit normal angiogenesis in the bone collar and apoptosis in hypertrophic chondrocytes

rickets ( J:191589 )

• calcification is inhibited at E17.5 and E18.5

failure of endochondral bone ossification ( J:191589 )

• endochondral ossification stopped at the hypertrophic stage

Allelic Composition	Sp7^tm1Rnis/Sp7^tm1Rnis Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: C57BL * C57BL/6 * CBA/JNCrlj * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sp7^tm1Rnis mutation (1 available); any Sp7 mutation (21 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Impairment of ossification in various conditional Sp7^tm1Rnis/Sp7^tm1Rnis mice

skeleton

failure of endochondral bone ossification ( J:191589 )

• endochondral ossification stopped at the hypertrophic stage

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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