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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Thy1-APPArc)M8Cagr
transgene insertion M8, Caroline Graff
MGI:5463435
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Thy1-APPArc)M8Cagr/Tg(Thy1-APPArc)M8Cagr involves: C57BL/6 * CBA MGI:5465558
tg2
Tg(Thy1-APPArc)M8Cagr/0 involves: C57BL/6 * CBA MGI:5463438


Genotype
MGI:5465558
tg1
Allelic
Composition
Tg(Thy1-APPArc)M8Cagr/Tg(Thy1-APPArc)M8Cagr
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• both males and females exhibit amyloid beta deposits in the brain, however females show more severe neuropathological alternations than males when compared at the same age and thus all further analysis was performed with females
• females exhibit intracellular amyloid beta aggregates in subiculum and pyramidal cells in CA1 and cortical layer V at 3 months of age, accumulation of diffuse extracellular amyloid beta in subiculum, alveus, and the retropsplenial granular cortex at 4 months of age, diffuse amyloid beta accumulation in thalamus, mammillary bodies, fimbria, fornix, motor cortex, and sensory cortex at 9 months of age, and additional diffuse accumulation in the entorhinal cortex, piriform cortex, lateral septum, and pons/medulla at 12-15 months of age
• females exhibit amyloid beta 40 and amyloid beta 42 immunoreactivity in plaque-like structures in subiculum at 6 months of age, and additionally in the thalamus, alveus, mammillary bodies, lateral septum, and pons/medulla, and around vessel walls in thalamus and subiculum at 12-15 months of age

homeostasis/metabolism
• both males and females exhibit amyloid beta deposits in the brain, however females show more severe neuropathological alternations than males when compared at the same age and thus all further analysis was performed with females
• females exhibit intracellular amyloid beta aggregates in subiculum and pyramidal cells in CA1 and cortical layer V at 3 months of age, accumulation of diffuse extracellular amyloid beta in subiculum, alveus, and the retropsplenial granular cortex at 4 months of age, diffuse amyloid beta accumulation in thalamus, mammillary bodies, fimbria, fornix, motor cortex, and sensory cortex at 9 months of age, and additional diffuse accumulation in the entorhinal cortex, piriform cortex, lateral septum, and pons/medulla at 12-15 months of age
• females exhibit amyloid beta 40 and amyloid beta 42 immunoreactivity in plaque-like structures in subiculum at 6 months of age, and additionally in the thalamus, alveus, mammillary bodies, lateral septum, and pons/medulla, and around vessel walls in thalamus and subiculum at 12-15 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:188191




Genotype
MGI:5463438
tg2
Allelic
Composition
Tg(Thy1-APPArc)M8Cagr/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mutants exhibit normal motor activity, exploratory behavior, and vertical activity in the open-field test at all ages tested
• in the Barnes maze, mutant females exhibit longer latency to find the target hole during the acquisition phase and the reversal learning phase compared to wild-type females, however no differences are seen between mutant and wild-type males, indicating impaired spatial learning and memory in 15 month old females
• in the Barnes maze, mutant females exhibit longer latency to find the target hole during the reversal learning phase compared to wild-type females, indicating impaired long-term learning and memory
• in a delayed alternation test, mutants show a longer latency to find the escape platform at 15 months of age compared to wild-type mice, indicating a minor impairment in working memory

nervous system
• amyloid beta plaques are evident in the subiculum and thalamus at 7 months and 18 months of age, respectively
• amyloid beta deposition is seen around vessel walls and in the parenchyma
• females exhibit higher levels of amyloid beta deposits than males

homeostasis/metabolism
• amyloid beta plaques are evident in the subiculum and thalamus at 7 months and 18 months of age, respectively
• amyloid beta deposition is seen around vessel walls and in the parenchyma
• females exhibit higher levels of amyloid beta deposits than males

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:168288





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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory