Mouse Genome Informatics
tg1
    Tg(Thy1-APPArc)M8Cagr/Tg(Thy1-APPArc)M8Cagr
involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• both males and females exhibit amyloid beta deposits in the brain, however females show more severe neuropathological alternations than males when compared at the same age and thus all further analysis was performed with females
• females exhibit intracellular amyloid beta aggregates in subiculum and pyramidal cells in CA1 and cortical layer V at 3 months of age, accumulation of diffuse extracellular amyloid beta in subiculum, alveus, and the retropsplenial granular cortex at 4 months of age, diffuse amyloid beta accumulation in thalamus, mammillary bodies, fimbria, fornix, motor cortex, and sensory cortex at 9 months of age, and additional diffuse accumulation in the entorhinal cortex, piriform cortex, lateral septum, and pons/medulla at 12-15 months of age
• females exhibit amyloid beta 40 and amyloid beta 42 immunoreactivity in plaque-like structures in subiculum at 6 months of age, and additionally in the thalamus, alveus, mammillary bodies, lateral septum, and pons/medulla, and around vessel walls in thalamus and subiculum at 12-15 months of age

homeostasis/metabolism
• both males and females exhibit amyloid beta deposits in the brain, however females show more severe neuropathological alternations than males when compared at the same age and thus all further analysis was performed with females
• females exhibit intracellular amyloid beta aggregates in subiculum and pyramidal cells in CA1 and cortical layer V at 3 months of age, accumulation of diffuse extracellular amyloid beta in subiculum, alveus, and the retropsplenial granular cortex at 4 months of age, diffuse amyloid beta accumulation in thalamus, mammillary bodies, fimbria, fornix, motor cortex, and sensory cortex at 9 months of age, and additional diffuse accumulation in the entorhinal cortex, piriform cortex, lateral septum, and pons/medulla at 12-15 months of age
• females exhibit amyloid beta 40 and amyloid beta 42 immunoreactivity in plaque-like structures in subiculum at 6 months of age, and additionally in the thalamus, alveus, mammillary bodies, lateral septum, and pons/medulla, and around vessel walls in thalamus and subiculum at 12-15 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:188191


Mouse Genome Informatics
tg2
    Tg(Thy1-APPArc)M8Cagr/0
involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
N
• mutants exhibit normal motor activity, exploratory behavior, and vertical activity in the open-field test at all ages tested (J:168288)
• in the Barnes maze, mutant females exhibit longer latency to find the target hole during the acquisition phase and the reversal learning phase compared to wild-type females, however no differences are seen between mutant and wild-type males, indicating impaired spatial learning and memory in 15 month old females (J:168288)
• in the Barnes maze, mutant females exhibit longer latency to find the target hole during the reversal learning phase compared to wild-type females, indicating impaired long-term learning and memory (J:168288)
• in a delayed alternation test, mutants show a longer latency to find the escape platform at 15 months of age compared to wild-type mice, indicating a minor impairment in working memory

nervous system
• amyloid beta deposition is seen around vessel walls and in the parenchyma
• amyloid beta plaques are evident in the subiculum and thalamus at 7 months and 18 months of age, respectively
• females exhibit higher levels of amyloid beta deposits than males

homeostasis/metabolism
• amyloid beta plaques are evident in the subiculum and thalamus at 7 months and 18 months of age, respectively
• amyloid beta deposition is seen around vessel walls and in the parenchyma
• females exhibit higher levels of amyloid beta deposits than males

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:168288