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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(SOD1*G85R)#Roos
transgene insertion, Raymond Roos
MGI:5448547
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(SOD1)2Gur/0
Tg(SOD1*G85R)#Roos/0
involves: C57BL/6 * C57BL/6J * SJL MGI:5448549
tg2
Tg(SOD1*G85R)#Roos/0 involves: C57BL/6J MGI:5448548


Genotype
MGI:5448549
cx1
Allelic
Composition
Tg(SOD1)2Gur/0
Tg(SOD1*G85R)#Roos/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SOD1)2Gur mutation (2 available)
Tg(SOD1*G85R)#Roos mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean survival is 185 days (J:147156)
• mean survival is 185 days (J:147156)

behavior/neurological
• progressive paralysis (J:147156)
• earlier onset (at about 131 days of age) of disease than single Tg(SOD1*G85R)#Roos mutants (at around 307 days of age), however disease duration is similar (J:147156)
• progressive paralysis (J:147156)
• earlier onset (at about 131 days of age) of disease than single Tg(SOD1*G85R)#Roos mutants (at around 307 days of age), however disease duration is similar (J:147156)

growth/size/body
• weight loss begins at 131 days of age (J:147156)
• weight loss begins at 131 days of age (J:147156)

nervous system
• in the anterior horn of the spinal cord at 150 days of age (J:147156)
• in the anterior horn of the spinal cord at 150 days of age (J:147156)
• SOD1-immunoreactive aggregates (of G85R mutant and wild-type SOD1 heterodimers, wild-type SOD1 homodimers and G85R mutant homodimers) are seen in motor neuron cells in the anterior horn at 150 days of age (J:147156)
• SOD1-immunoreactive aggregates (of G85R mutant and wild-type SOD1 heterodimers, wild-type SOD1 homodimers and G85R mutant homodimers) are seen in motor neuron cells in the anterior horn at 150 days of age (J:147156)
• loss of motor neurons at 150 days of age and loss of motor neuron connections with muscle in the lumbar spinal cord anterior horn (J:147156)
• loss of motor neurons at 150 days of age and loss of motor neuron connections with muscle in the lumbar spinal cord anterior horn (J:147156)

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:147156




Genotype
MGI:5448548
tg2
Allelic
Composition
Tg(SOD1*G85R)#Roos/0
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean survival is 349 days (J:147156)
• mean survival is 349 days (J:147156)

behavior/neurological
• progressive paralysis (J:147156)
• progressive paralysis (J:147156)

growth/size/body
• weight loss begins at 307 days of age (J:147156)
• weight loss begins at 307 days of age (J:147156)

nervous system
• in the anterior horn of the spinal cord at 350 days of age (J:147156)
• in the anterior horn of the spinal cord at 350 days of age (J:147156)
• SOD1-immunoreactive aggregates (of mutant SOD1 homodimers) are seen in motor neuron cells in the anterior horn at 350 days of age (J:147156)
• SOD1-immunoreactive aggregates (of mutant SOD1 homodimers) are seen in motor neuron cells in the anterior horn at 350 days of age (J:147156)
• loss of motor neurons at 350 days of age but not at 150 days of age (J:147156)
• loss of motor neurons at 350 days of age but not at 150 days of age (J:147156)

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:147156





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory