Phenotypes associated with this allele

• Allele Symbol: Tg(Fabp4-SREBF1)#Dajl
• Allele Name: transgene insertion, David J Lloyd
• Allele ID: MGI:5446499
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Fabp4-SREBF1)#Dajl/0	involves: FVB	MGI:5446500

Genotype
MGI:5446500

tg1

• Allelic Composition: Tg(Fabp4-SREBF1)#Dajl/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Lipodystrophy in Tg(Fabp4-SREBF1)#Dajl/0 males

adipose tissue

decreased white adipose tissue amount ( J:189510 )

• dramatically reduced WAT depot weights

lipodystrophy ( J:189510 )

• dramatic decrease in fat mass

• however, body weight is similar to wild-type controls

homeostasis/metabolism

hyperglycemia ( J:189510 )

increased circulating insulin level ( J:189510 )

impaired glucose tolerance ( J:189510 )

• mild or sporadic glucose intolerance

insulin resistance ( J:189510 )

• severe

decreased triglyceride level ( J:189510 )

behavior/neurological

increased food intake ( J:189510 )

• mild increase

growth/size/body

increased lean body mass ( J:189510 )

enlarged liver ( J:189510 )

liver/biliary system

enlarged liver ( J:189510 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lipodystrophy		DOID:811		J:189510