• mice exhibit an increase in the number of slow/fast oxidative fibers compared with wild-type mice

• mice develop nemaline rods in muscles resulting in Z line streaming and disruption of sarcomeric register

• mice develop cytoplasmic bodies and tubular aggregates of the sarcoplasmic reticulum

• the number of fibers containing rods and rod size is different in different muscles

• mice exhibit hypertrophy of fast, glycolytic fibers

• skinner fibers exhibit minor changes in response to strontium sensitivity compared with wild-type fibers

• late onset

• nemaline myopathy