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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(ACTA1-TPM3*M9R)4Hrd
transgene insertion 4, Edna Hardeman
MGI:5444208
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(ACTA1-TPM3*M9R)4Hrd/0 FVB/NJ-Tg(ACTA1-TPM3*M9R)4Hrd MGI:5444222


Genotype
MGI:5444222
tg1
Allelic
Composition
Tg(ACTA1-TPM3*M9R)4Hrd/0
Genetic
Background
FVB/NJ-Tg(ACTA1-TPM3*M9R)4Hrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTA1-TPM3*M9R)4Hrd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• mice exhibit an increase in the number of slow/fast oxidative fibers compared with wild-type mice
• mice develop nemaline rods in muscles resulting in Z line streaming and disruption of sarcomeric register
• mice develop cytoplasmic bodies and tubular aggregates of the sarcoplasmic reticulum
• the number of fibers containing rods and rod size is different in different muscles
• mice exhibit hypertrophy of fast, glycolytic fibers
• skinner fibers exhibit minor changes in response to strontium sensitivity compared with wild-type fibers
• late onset
• nemaline myopathy

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
nemaline myopathy 1 DOID:0110926 OMIM:609284
J:67596





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last database update
08/15/2017
MGI 6.10
The Jackson Laboratory