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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(ACTA1-TPM3*M9R)4Hrd
transgene insertion 4, Edna Hardeman
MGI:5444208
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(ACTA1-TPM3*M9R)4Hrd/0 FVB/NJ-Tg(ACTA1-TPM3*M9R)4Hrd MGI:5444222


Genotype
MGI:5444222
tg1
Allelic
Composition
Tg(ACTA1-TPM3*M9R)4Hrd/0
Genetic
Background
FVB/NJ-Tg(ACTA1-TPM3*M9R)4Hrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTA1-TPM3*M9R)4Hrd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• mice exhibit an increase in the number of slow/fast oxidative fibers compared with wild-type mice (J:67596)
• mice exhibit an increase in the number of slow/fast oxidative fibers compared with wild-type mice (J:67596)
• mice develop nemaline rods in muscles resulting in Z line streaming and disruption of sarcomeric register (J:67596)
• mice develop cytoplasmic bodies and tubular aggregates of the sarcoplasmic reticulum (J:67596)
• the number of fibers containing rods and rod size is different in different muscles (J:67596)
• mice develop nemaline rods in muscles resulting in Z line streaming and disruption of sarcomeric register (J:67596)
• mice develop cytoplasmic bodies and tubular aggregates of the sarcoplasmic reticulum (J:67596)
• the number of fibers containing rods and rod size is different in different muscles (J:67596)
• mice exhibit hypertrophy of fast, glycolytic fibers (J:67596)
• mice exhibit hypertrophy of fast, glycolytic fibers (J:67596)
• skinner fibers exhibit minor changes in response to strontium sensitivity compared with wild-type fibers (J:67596)
• skinner fibers exhibit minor changes in response to strontium sensitivity compared with wild-type fibers (J:67596)
• late onset (J:67596)
• late onset (J:67596)
• nemaline myopathy (J:67596)
• nemaline myopathy (J:67596)

Mouse Models of Human Disease
OMIM ID Ref(s)
Nemaline Myopathy 1; NEM1 609284 J:67596





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory