Mouse Genome Informatics
cx1
    Rhotm1Phm/Rho+
Tg(Rho*G90D*A337V)202Sie/0

involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
N
• mice exhibit normal outer nuclear layer thickness, retinal outer segment length, photoreceptor numbers and rhodopsin complement (J:188632)
• at 16 weeks, mice exhibit reduced maximal a-wave amplitude and increased a-wave threshold compared with Rhotm1Phm heterozygotes
• mice exhibit loss of rod sensitivity with rod photoreceptor desensitization and faster response time to peak compared with Rhotm1Phm heterozygotes
• rods exhibit a partially light-adapted phenotype


Mouse Genome Informatics
cx2
    Rhotm1Phm/Rho+
Tg(Rho*G90D*A337V)202Sie/Tg(Rho*G90D*A337V)202Sie

involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
N
• normal rod outer segments and minimal rod cell loss (J:188632)
• at 24 weeks, mice exhibit reduced maximal a- and b-wave amplitude and increased a- and b-wave threshold compared with Rhotm1Phm heterozygotes
• increased equivalent background light level
• rods exhibit a partially light-adapted phenotype


Mouse Genome Informatics
cx3
    Rhotm1Phm/Rhotm1Phm
Tg(Rho*G90D*A337V)202Sie/0

involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
N
• mice develop outer segments unlike Rhotm1Phm homozygotes (J:188632)
• slower than in Rhotm1Phm homozygotes
• 60% of normal at 14 weeks

nervous system
• slower than in Rhotm1Phm homozygotes


Mouse Genome Informatics
cx4
    Rhotm1Phm/Rhotm1Phm
Tg(Rho*G90D*A337V)202Sie/Tg(Rho*G90D*A337V)202Sie

involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye

nervous system


Mouse Genome Informatics
tg5
    Tg(Rho*G90D*A337V)202Sie/0
involves: C57BL/6 * DBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
N
• unlike other models of nightblindness, mice do not exhibit loss of rods (J:188632)
• reduced dark-adapted b-wave threshold without rod degeneration
• rod sensitivity is depressed and required higher flash intensity
• for half maximal responses, the time to pear is faster than for wild-type mice