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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Rho*G90D*A337V)202Sie
transgene insertion 202, Paul A Sieving
MGI:5441362
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Rhotm1Phm/Rho+
Tg(Rho*G90D*A337V)202Sie/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA MGI:5441374
cx2
Rhotm1Phm/Rho+
Tg(Rho*G90D*A337V)202Sie/Tg(Rho*G90D*A337V)202Sie
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA MGI:5441375
cx3
Rhotm1Phm/Rhotm1Phm
Tg(Rho*G90D*A337V)202Sie/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA MGI:5441376
cx4
Rhotm1Phm/Rhotm1Phm
Tg(Rho*G90D*A337V)202Sie/Tg(Rho*G90D*A337V)202Sie
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA MGI:5441377
tg5
Tg(Rho*G90D*A337V)202Sie/0 involves: C57BL/6 * DBA MGI:5441373


Genotype
MGI:5441374
cx1
Allelic
Composition
Rhotm1Phm/Rho+
Tg(Rho*G90D*A337V)202Sie/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1Phm mutation (0 available); any Rho mutation (22 available)
Tg(Rho*G90D*A337V)202Sie mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• mice exhibit normal outer nuclear layer thickness, retinal outer segment length, photoreceptor numbers and rhodopsin complement
• at 16 weeks, mice exhibit reduced maximal a-wave amplitude and increased a-wave threshold compared with Rhotm1Phm heterozygotes
• mice exhibit loss of rod sensitivity with rod photoreceptor desensitization and faster response time to peak compared with Rhotm1Phm heterozygotes
• rods exhibit a partially light-adapted phenotype




Genotype
MGI:5441375
cx2
Allelic
Composition
Rhotm1Phm/Rho+
Tg(Rho*G90D*A337V)202Sie/Tg(Rho*G90D*A337V)202Sie
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1Phm mutation (0 available); any Rho mutation (22 available)
Tg(Rho*G90D*A337V)202Sie mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• normal rod outer segments and minimal rod cell loss
• at 24 weeks, mice exhibit reduced maximal a- and b-wave amplitude and increased a- and b-wave threshold compared with Rhotm1Phm heterozygotes
• increased equivalent background light level
• rods exhibit a partially light-adapted phenotype




Genotype
MGI:5441376
cx3
Allelic
Composition
Rhotm1Phm/Rhotm1Phm
Tg(Rho*G90D*A337V)202Sie/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1Phm mutation (0 available); any Rho mutation (22 available)
Tg(Rho*G90D*A337V)202Sie mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• mice develop outer segments unlike Rhotm1Phm homozygotes
• slower than in Rhotm1Phm homozygotes
• 60% of normal at 14 weeks

nervous system
• slower than in Rhotm1Phm homozygotes




Genotype
MGI:5441377
cx4
Allelic
Composition
Rhotm1Phm/Rhotm1Phm
Tg(Rho*G90D*A337V)202Sie/Tg(Rho*G90D*A337V)202Sie
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1Phm mutation (0 available); any Rho mutation (22 available)
Tg(Rho*G90D*A337V)202Sie mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:5441373
tg5
Allelic
Composition
Tg(Rho*G90D*A337V)202Sie/0
Genetic
Background
involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• unlike other models of nightblindness, mice do not exhibit loss of rods
• reduced dark-adapted b-wave threshold without rod degeneration
• rod sensitivity is depressed and required higher flash intensity
• for half maximal responses, the time to pear is faster than for wild-type mice





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory