Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1Phm mutation
(2 available);
any
Rho mutation
(48 available)
Tg(Rho*G90D*A337V)202Sie mutation
(0 available)
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vision/eye
N |
• mice exhibit normal outer nuclear layer thickness, retinal outer segment length, photoreceptor numbers and rhodopsin complement
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• at 16 weeks, mice exhibit reduced maximal a-wave amplitude and increased a-wave threshold compared with Rhotm1Phm heterozygotes
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• mice exhibit loss of rod sensitivity with rod photoreceptor desensitization and faster response time to peak compared with Rhotm1Phm heterozygotes
• rods exhibit a partially light-adapted phenotype
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1Phm mutation
(2 available);
any
Rho mutation
(48 available)
Tg(Rho*G90D*A337V)202Sie mutation
(0 available)
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vision/eye
N |
• normal rod outer segments and minimal rod cell loss
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• at 24 weeks, mice exhibit reduced maximal a- and b-wave amplitude and increased a- and b-wave threshold compared with Rhotm1Phm heterozygotes
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• increased equivalent background light level
• rods exhibit a partially light-adapted phenotype
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1Phm mutation
(2 available);
any
Rho mutation
(48 available)
Tg(Rho*G90D*A337V)202Sie mutation
(0 available)
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vision/eye
N |
• mice develop outer segments unlike Rhotm1Phm homozygotes
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• slower than in Rhotm1Phm homozygotes
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• 60% of normal at 14 weeks
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nervous system
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• slower than in Rhotm1Phm homozygotes
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1Phm mutation
(2 available);
any
Rho mutation
(48 available)
Tg(Rho*G90D*A337V)202Sie mutation
(0 available)
|
|
|
vision/eye
nervous system
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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vision/eye
N |
• unlike other models of nightblindness, mice do not exhibit loss of rods
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• reduced dark-adapted b-wave threshold without rod degeneration
• rod sensitivity is depressed and required higher flash intensity
• for half maximal responses, the time to pear is faster than for wild-type mice
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