Mouse Genome Informatics
cx1
    Tg(BCL2)25Wehi/0
Tg(Igkv3-5*-MYC)#Plbe/0

involves: C57BL/6 * C57BL/6JWehi * SJL/JWehi
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• median survival is 337 days

tumorigenesis
• aggressive extramedullary monoclonal plasmacytoma with infiltration of spleen and lymph nodes


Mouse Genome Informatics
cx2
    Aicdatm1Hon/Aicdatm1Hon
Tg(Igkv3-5*-MYC)#Plbe/0

involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• unlike Tg(Igkv3-5*-Myc)#Plbe mice, no spikes in monoclonal antibodies (M-spikes) are observed (J:131912)
• mice exhibit fewer plasma cells in the bone marrow compared with Tg(Igkv3-5*-Myc)#Plbe mice (J:131912)


Mouse Genome Informatics
tg3
    Tg(Igkv3-5*-MYC)#Plbe/0
involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• median survival of 594 days in 2 of 8 mice following secondary immunization with NP-CGG
• median survival of 661 days

immune system
• slowly progressive monoclonal expansion exclusively in the bone marrow
• extramedullary plasma cell expansion
• mice exhibit a spike in monoclonal antibodies (M-spikes) starting at 20 weeks of age that increases with age
• following secondary immunization, 2 of 8 mice immunized with NP-CGG exhibit M-spikes unlike control mice
• however, mice treated with melphalan, dexamethasone, and bortezomib exhibit reduced M-spike levels
• two mice develop type 1 cryoglobulinemia
• serum immunoglobin detected in the tubuli and glomeruli of the kidney
• at 70 weeks
• at 70 weeks

hematopoietic system
• lower median hemoglobin concentration at necropsy
• slowly progressive monoclonal expansion exclusively in the bone marrow
• extramedullary plasma cell expansion
• two mice develop type 1 cryoglobulinemia
• serum immunoglobin detected in the tubuli and glomeruli of the kidney
• at 70 weeks
• at 70 weeks

skeleton
• vertebral collapse occasionally observed
• lytic bone lesions occasionally observed

tumorigenesis
• 2 of 122 mice develop very aggressive, highly proliferative, isotype class-switched, somatically mutate Burkitt's lymphoma that invade multiple organs and infiltrate the bone marrow, disappearance of M-spikes and reversion of the mutated stop codon
• in aged mice, confined to the bone marrow
• clonally related, proliferative, extramedullary plasmacytoma in some mice that spreads to the spleen, lymph nodes and peritoneal cavity with ascites
• following secondary immunization, 2 of 8 mice immunized with NP-CGG exhibit increased incidence of progression to extramedullary plasmacytoma unlike control mice

behavior/neurological
• occasionally

homeostasis/metabolism
• in some mice with plasmacytoma

Mouse Models of Human Disease
OMIM IDRef(s)
Myeloma, Multiple 254500 J:131912