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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Igkv3-5*-MYC)#Plbe
transgene insertion, P Leif Bergsagel
MGI:5441311
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(BCL2)25Wehi/0
Tg(Igkv3-5*-MYC)#Plbe/0
involves: C57BL/6 * C57BL/6JWehi * SJL/JWehi MGI:5441334
cx2
Aicdatm1Hon/Aicdatm1Hon
Tg(Igkv3-5*-MYC)#Plbe/0
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj MGI:5441335
tg3
Tg(Igkv3-5*-MYC)#Plbe/0 involves: C57BL/6 MGI:5441332


Genotype
MGI:5441334
cx1
Allelic
Composition
Tg(BCL2)25Wehi/0
Tg(Igkv3-5*-MYC)#Plbe/0
Genetic
Background
involves: C57BL/6 * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)25Wehi mutation (1 available)
Tg(Igkv3-5*-MYC)#Plbe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is 337 days

neoplasm
• aggressive extramedullary monoclonal plasmacytoma with infiltration of spleen and lymph nodes




Genotype
MGI:5441335
cx2
Allelic
Composition
Aicdatm1Hon/Aicdatm1Hon
Tg(Igkv3-5*-MYC)#Plbe/0
Genetic
Background
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (32 available)
Tg(Igkv3-5*-MYC)#Plbe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• unlike Tg(Igkv3-5*-Myc)#Plbe mice, no spikes in monoclonal antibodies (M-spikes) are observed
• mice exhibit fewer plasma cells in the bone marrow compared with Tg(Igkv3-5*-Myc)#Plbe mice




Genotype
MGI:5441332
tg3
Allelic
Composition
Tg(Igkv3-5*-MYC)#Plbe/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival of 594 days in 2 of 8 mice following secondary immunization with NP-CGG
• median survival of 661 days

immune system
• extramedullary plasma cell expansion
• slowly progressive monoclonal expansion exclusively in the bone marrow
• mice exhibit a spike in monoclonal antibodies (M-spikes) starting at 20 weeks of age that increases with age
• following secondary immunization, 2 of 8 mice immunized with NP-CGG exhibit M-spikes unlike control mice
• however, mice treated with melphalan, dexamethasone, and bortezomib exhibit reduced M-spike levels
• two mice develop type 1 cryoglobulinemia
• serum immunoglobin detected in the tubuli and glomeruli of the kidney
• at 70 weeks
• at 70 weeks

hematopoietic system
• extramedullary plasma cell expansion
• lower median hemoglobin concentration at necropsy
• slowly progressive monoclonal expansion exclusively in the bone marrow
• two mice develop type 1 cryoglobulinemia
• serum immunoglobin detected in the tubuli and glomeruli of the kidney
• at 70 weeks
• at 70 weeks

skeleton
• vertebral collapse occasionally observed
• lytic bone lesions occasionally observed

neoplasm
• 2 of 122 mice develop very aggressive, highly proliferative, isotype class-switched, somatically mutate Burkitt's lymphoma that invade multiple organs and infiltrate the bone marrow, disappearance of M-spikes and reversion of the mutated stop codon
• in aged mice, confined to the bone marrow
• clonally related, proliferative, extramedullary plasmacytoma in some mice that spreads to the spleen, lymph nodes and peritoneal cavity with ascites
• following secondary immunization, 2 of 8 mice immunized with NP-CGG exhibit increased incidence of progression to extramedullary plasmacytoma unlike control mice

behavior/neurological
• occasionally

homeostasis/metabolism
• in some mice with plasmacytoma

Mouse Models of Human Disease
OMIM ID Ref(s)
Myeloma, Multiple 254500 J:131912





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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory