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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Igkv3-5*-MYC)#Plbe
transgene insertion, P Leif Bergsagel
MGI:5441311
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(BCL2)25Wehi/0
Tg(Igkv3-5*-MYC)#Plbe/0 		involves: C57BL/6 * C57BL/6JWehi * SJL/JWehi MGI:5441334
cx2
 		Aicdatm1Hon/Aicdatm1Hon
Tg(Igkv3-5*-MYC)#Plbe/0 		involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj MGI:5441335


Genotype
MGI:5441334
cx1
Allelic
Composition		 Tg(BCL2)25Wehi/0
Tg(Igkv3-5*-MYC)#Plbe/0
Genetic
Background		 involves: C57BL/6 * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)25Wehi mutation (1 available)
Tg(Igkv3-5*-MYC)#Plbe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:131912 )
• median survival is 337 days

neoplasm
increased plasmacytoma incidence ( J:131912 )
• aggressive extramedullary monoclonal plasmacytoma with infiltration of spleen and lymph nodes




Genotype
MGI:5441335
cx2
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Tg(Igkv3-5*-MYC)#Plbe/0
Genetic
Background		 involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (55 available)
Tg(Igkv3-5*-MYC)#Plbe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:131912 )
N
• unlike Tg(Igkv3-5*-Myc)#Plbe mice, no spikes in monoclonal antibodies (M-spikes) are observed
• mice exhibit fewer plasma cells in the bone marrow compared with Tg(Igkv3-5*-Myc)#Plbe mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory