Phenotypes associated with this allele

• Allele Symbol: Kpna1^tm1.2Yyo
• Allele Name: targeted mutation 1.2, Yoshihiro Yoneda
• Allele ID: MGI:5439493
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kpna1^tm1.2Yyo/Kpna1^tm1.2Yyo	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:5439540

Genotype
MGI:5439540

hm1

• Allelic Composition: Kpna1^tm1.2Yyo/Kpna1^tm1.2Yyo
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

vaginal hemorrhage ( J:188099 )

♀ • some mice exhibit vaginal bleeding near the time of delivery

mortality/aging

pregnancy-related premature death ( J:188099 )

♀ • 5 of 17 female mice die during birthing

reproductive system

reproductive system phenotype ( J:188099 )

♂N • male mice exhibit normal fertility

vaginal hemorrhage ( J:188099 )

♀ • some mice exhibit vaginal bleeding near the time of delivery

decreased mature ovarian follicle number ( J:188099 )

♀ • however, gonadotrophin treatment rescues mature oocyte development

abnormal uterus morphology ( J:188099 )

♀ • thin myometrium, stromal and epithelial layers

abnormal endometrial gland development ( J:188099 )

♀ • immature endometrial glands

thin myometrium ( J:188099 )

♀

abnormal uterus development ( J:188099 )

♀ • after treatment with exogenous gonadotropin despite rescue of mature oocyte

dystocia ( J:188099 )

♀ • in some mice

decreased litter size ( J:188099 )

♀ • from female mice mated to wild-type or heterozygous mice

♀ • dead pups have twisted bodies and/or bite marks

homeostasis/metabolism

decreased circulating progesterone level ( J:188099 )

♀

decreased circulating cholesterol level ( J:188099 )

increased circulating alanine transaminase level ( J:188099 )

• mild

increased circulating aspartate transaminase level ( J:188099 )

• mild

hematopoietic system

thrombocytopenia ( J:188099 )

liver/biliary system

liver/biliary system phenotype ( J:188099 )

N • liver histology and apoptosis is normal

endocrine/exocrine glands

abnormal endometrial gland development ( J:188099 )

♀ • immature endometrial glands

decreased mature ovarian follicle number ( J:188099 )

♀ • however, gonadotrophin treatment rescues mature oocyte development