About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nlgn3tm1Rhn
targeted mutation 1, Rene Hen
MGI:5439278
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Nlgn3tm1Rhn/Nlgn3+ involves: 129S6/SvEvTac MGI:5440439
cx2
Nlgn3tm1Rhn/Y
Tg(Pcp2-tTA)3Horr/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:5440732
ot3
Nlgn3tm1Rhn/Y involves: 129S6/SvEvTac * C57BL/6 MGI:5440731


Genotype
MGI:5440439
ht1
Allelic
Composition
Nlgn3tm1Rhn/Nlgn3+
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm1Rhn mutation (1 available); any Nlgn3 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed




Genotype
MGI:5440732
cx2
Allelic
Composition
Nlgn3tm1Rhn/Y
Tg(Pcp2-tTA)3Horr/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm1Rhn mutation (1 available); any Nlgn3 mutation (16 available)
Tg(Pcp2-tTA)3Horr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice in the absence of doxycycline (Nlgn3 expression is on) exhibit rescue of the neurological phenotypes seen in Nlgn3 single hemizygotes
• mutants raised in the presence of doxycycline (Nlgn3 expression is off) and then the doxycycline is removed to allow for Nlgn3 reexpression, exhibit removal of ectopic synapses from the distal Purkinje cell dendritic tree




Genotype
MGI:5440731
ot3
Allelic
Composition
Nlgn3tm1Rhn/Y
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm1Rhn mutation (1 available); any Nlgn3 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• on an Erasmus ladder, mutants complete the same number of valid runs on the ladder as wild-type mice, however, step times for mutants are significantly elevated, indicating perturbed motor coordination

nervous system
• mutants exhibit extensive ectopic synapse formation in the distal Purkinje cell dendritic tree
• mutants exhibit perturbed metabotropic glutamate receptor-dependent synaptic plasticity
• evoked climbing fiber-Purkinje cell transmission is increased as indicated by an increase in climbing fiber evoked excitatory postsynaptic current (EPSC) amplitude; elevation is due to an increase in the total number of climbing fiber synapses
• small, but significant, reduction in miniature excitatory postsynaptic current (mEPSC) amplitude
• however, paired-pulse facilitation of parallel fiber synapse is not altered
• mutants do not exhibit the reduction of EPSC amplitudes in response to group I mGluR agonist DHPG in cerebellar slices seen in controls, indicating a loss of metabotropic glutamate receptor-dependent long-term depression (mGluR-LTP)

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism, Susceptibility to, X-Linked 1; AUTSX1 300425 J:187744





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/26/2016
MGI 6.03
The Jackson Laboratory