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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dock8tm1Ysfk
targeted mutation 1, Yoshinori Fukui
MGI:5437274
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dock8tm1Ysfk/Dock8tm1Ysfk B6.Cg-Dock8tm1Ysfk MGI:5437279


Genotype
MGI:5437279
hm1
Allelic
Composition
Dock8tm1Ysfk/Dock8tm1Ysfk
Genetic
Background
B6.Cg-Dock8tm1Ysfk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock8tm1Ysfk mutation (0 available); any Dock8 mutation (103 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• after ovalbumin stimulation of CD4+ T cells
• in the spleen and peripheral lymph node
• in the spleen and peripheral lymph node
• after ovalbumin stimulation
• in draining lymph nodes during immune response
• dendritic cell (DC) trafficking during immune response is impaired compared to in wild-type cells
• DC exhibit impaired migration in 3D environments compared with wild-type cells
• DC exhibit impaired transmigration through subcapsular sinus compared with wild-type cells
• however, migration in a 2D environments is normal

hematopoietic system
• after ovalbumin stimulation of CD4+ T cells
• in the spleen and peripheral lymph node
• in the spleen and peripheral lymph node
• after ovalbumin stimulation

cellular
• after ovalbumin stimulation of CD4+ T cells





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory