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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fezf2tm1.1Nses
targeted mutation 1.1, Nenad Sestan
MGI:5433045
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Fezf2tm1.1Nses/Fezf2tm1.1Nses
Emx1tm1(cre)Ito/Emx1+
involves: 129P2/OlaHsd * 129S1/Sv MGI:5433183
cn2
Fezf2tm1.1Nses/Fezf2tm1.1Nses
Tbr1tm1Jlr/Tbr1tm1Jlr
Tg(Emx1-cre)#Ito/0
Tg(Mbp-MAPT/EGFP)#Eja/0
involves: 129S1/Sv * C57BL/6 MGI:5433181
cn3
Fezf2tm1.1Nses/Fezf2tm1.1Nses
Tg(CAG-cat,-EGFP)39Miya/0
Tg(Emx1-cre)#Ito/0
involves: 129S1/Sv * C57BL/6 * C57BL/6NJcl * DBA/2NJcl MGI:5433180


Genotype
MGI:5433183
cn1
Allelic
Composition
Fezf2tm1.1Nses/Fezf2tm1.1Nses
Emx1tm1(cre)Ito/Emx1+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Ito mutation (1 available); any Emx1 mutation (34 available)
Fezf2tm1.1Nses mutation (1 available); any Fezf2 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice lack corticospinal axons in the pons




Genotype
MGI:5433181
cn2
Allelic
Composition
Fezf2tm1.1Nses/Fezf2tm1.1Nses
Tbr1tm1Jlr/Tbr1tm1Jlr
Tg(Emx1-cre)#Ito/0
Tg(Mbp-MAPT/EGFP)#Eja/0
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fezf2tm1.1Nses mutation (1 available); any Fezf2 mutation (49 available)
Tbr1tm1Jlr mutation (1 available); any Tbr1 mutation (38 available)
Tg(Emx1-cre)#Ito mutation (0 available)
Tg(Mbp-MAPT/EGFP)#Eja mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Aberrant L6 projections to the brainstem in the Tbr1tm1Jlr/Tbr1tm1Jlr mice require Fezf2

nervous system
N
• unlike Tbr1tm1Jlr homozygotes, mice lack retrograde labeling of L5 and L6 projection neurons




Genotype
MGI:5433180
cn3
Allelic
Composition
Fezf2tm1.1Nses/Fezf2tm1.1Nses
Tg(CAG-cat,-EGFP)39Miya/0
Tg(Emx1-cre)#Ito/0
Genetic
Background
involves: 129S1/Sv * C57BL/6 * C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fezf2tm1.1Nses mutation (1 available); any Fezf2 mutation (49 available)
Tg(CAG-cat,-EGFP)39Miya mutation (1 available)
Tg(Emx1-cre)#Ito mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice lack corticospinal axons in the brainstem





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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory