Mouse Genome Informatics
tg1
    Tg(Dyrk1a)#Jmd/0
B6.129S2/SvPas-Tg(Dyrk1a)#Jmd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• viability is about 38% compared to the expected 50%

growth/size
• reduction in body weight during entire preweaning period continuing into adulthood, with a 20% reduction in weight at P30, however by P60, weight is normal
• reduction in body length during entire preweaning period continuing into adulthood, with a 20% reduction in length at P30, however by P60, length is normal
• developmental delay is seen at P15 and P30, however by P60, no difference is observed

craniofacial

nervous system
• the dorso-ventral length of the brain is enlarged
• increase in height of the central and more caudal part of the brain
• brain weight is larger at P21 but not at P0, averaging a 15% increase by adulthood
• increase in lateral ventricle volume
• increase in dorsal third ventricle volume, however the ventral third ventricle is unchanged
• increase in ventral posterolateral and ventral posteromedial thalamic nuclei volume (120% of control)
• 18% increase in cell density in the ventral posterolateral and ventral posteromedial thalamic nuclei due to higher neuronal density. however glial density is unchanged
• increase in hippocampal CA1-CA3 volume (115% of control)
• increase in dentate gyrus volume (115% of control)
• increase in hippocampal molecular layer volume but a decrease in cell density, indicating that total cell number is unchanged and that cell morphology is altered
• increase in hippocampal oriens layer volume but a decrease in cell density, indicating that total cell number is unchanged and that cell morphology is altered
• increase in cortical layer thickness at the somatosensory cortex; increase in thickness of cortical layers II/III, V, and VI, but no difference in layer IV
• 15% increase in thickness of cortical layers V and VI
• 13% increase in total thickness of the entorhinal cortex
• density of NeuN-labeled neurons in layers V and VI of the somatosensory cortex is decreased by 15-17%, however density in layer II/III and IV is normal
• while there is an increase in thickness of layers V and VI of the somatosensory cortex, the density of neurons in these layers is decreased, indicating that the total number of neurons is unchanged

Mouse Models of Human Disease
OMIM IDRef(s)
Down Syndrome 190685 J:182294