• viability is about 38% compared to the expected 50%

• reduction in body length during entire preweaning period continuing into adulthood, with a 20% reduction in length at P30, however by P60, length is normal

• reduction in body weight during entire preweaning period continuing into adulthood, with a 20% reduction in weight at P30, however by P60, weight is normal

• developmental delay is seen at P15 and P30, however by P60, no difference is observed

• the dorso-ventral length of the brain is enlarged

• increase in height of the central and more caudal part of the brain

• brain weight is larger at P21 but not at P0, averaging a 15% increase by adulthood

• increase in lateral ventricle volume

• increase in dorsal third ventricle volume, however the ventral third ventricle is unchanged

• increase in ventral posterolateral and ventral posteromedial thalamic nuclei volume (120% of control)

• 18% increase in cell density in the ventral posterolateral and ventral posteromedial thalamic nuclei due to higher neuronal density. however glial density is unchanged

• increase in hippocampal CA1-CA3 volume (115% of control)

• increase in dentate gyrus volume (115% of control)

• increase in hippocampal molecular layer volume but a decrease in cell density, indicating that total cell number is unchanged and that cell morphology is altered

• increase in hippocampal oriens layer volume but a decrease in cell density, indicating that total cell number is unchanged and that cell morphology is altered

• increase in cortical layer thickness at the somatosensory cortex; increase in thickness of cortical layers II/III, V, and VI, but no difference in layer IV

• 15% increase in thickness of cortical layers V and VI

• 13% increase in total thickness of the entorhinal cortex

• density of NeuN-labeled neurons in layers V and VI of the somatosensory cortex is decreased by 15-17%, however density in layer II/III and IV is normal

• while there is an increase in thickness of layers V and VI of the somatosensory cortex, the density of neurons in these layers is decreased, indicating that the total number of neurons is unchanged