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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno
targeted mutation 1, Genoway
MGI:5428335
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt+
Tg(PSEN1)5Dbo/0
involves: 129P2/OlaHsd MGI:5428425


Genotype
MGI:5428425
cx1
Allelic
Composition
Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt+
Tg(PSEN1)5Dbo/0
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno mutation (0 available); any Hprt mutation (1206 available)
Tg(PSEN1)5Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• at 5 months, mice exhibit impaired social recognition memory compared with control mice
• at 12 months, mice lack social recognition memory unlike control mice
• impaired at 8 months
• amnesia at 12 months
• at 12 months, mice exhibit impaired object recognition following spatial displacement compared with control mice
• impaired at 12 months
• mice exhibit higher swim speeds compared with control mice
• at 12 months, mice fail to exhibit a decline in activity during the day phase unlike control mice
• at 5 months mice exhibit increased wake time compared with control mice
• at 5 and 12 months, mice exhibit a decrease in rapid eye movement (REM) sleep compared with control mice
• at 5 months, mice exhibit a reduction in nonREM sleep compared with control mice
• at 12 months mice exhibit longer latency to sleep onset compared with control mice

nervous system
N
• mice do not develop fibrillary plaques or tangles
• mice exhibit a slowing of electroencephalogram compared with control mice
• mice exhibit faster decay of long term potentiation compared with control mice
• however, post-tetanic potentiation is normal

homeostasis/metabolism
• mice exhibit early and progressive brain glucose metabolism compared with control mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:180977





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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory