Mouse Genome Informatics
cx1
    Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt+
Tg(PSEN1)5Dbo/0

involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• at 5 months, mice exhibit impaired social recognition memory compared with control mice (J:180977)
• at 12 months, mice lack social recognition memory unlike control mice (J:180977)
• amnesia at 12 months (J:180977)
• impaired at 8 months (J:180977)
• at 12 months, mice exhibit impaired object recognition following spatial displacement compared with control mice (J:180977)
• impaired at 12 months (J:180977)
• mice exhibit higher swim speeds compared with control mice (J:180977)
• at 12 months, mice fail to exhibit a decline in activity during the day phase unlike control mice (J:180977)
• at 5 months mice exhibit increased wake time compared with control mice (J:180977)
• at 5 and 12 months, mice exhibit a decrease in rapid eye movement (REM) sleep compared with control mice (J:180977)
• at 5 months, mice exhibit a reduction in nonREM sleep compared with control mice (J:180977)
• at 12 months mice exhibit longer latency to sleep onset compared with control mice (J:180977)

nervous system
N
• mice do not develop fibrillary plaques or tangles (J:180977)
• mice exhibit a slowing of electroencephalogram compared with control mice (J:180977)
• mice exhibit faster decay of long term potentiation compared with control mice (J:180977)
• however, post-tetanic potentiation is normal (J:180977)

homeostasis/metabolism
• mice exhibit early and progressive brain glucose metabolism compared with control mice (J:180977)

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:180977