Mouse Genome Informatics
hm1
    Gata4tm1Grg/Gata4tm1Grg
involves: 129 * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Growth retardation and a thin myocardium in Gata4tm1Grg/Gata4tm1Grg mice

mortality/aging

growth/size
• severe growth retardation at E9.5 and E10.5

cardiovascular system
• some embryos show delayed or incomplete looping at E9.5 and E10.5
• severe thinning at E10.5

cellular

embryogenesis
• severe growth retardation at E9.5 and E10.5

muscle


Mouse Genome Informatics
ht2
    Gata4tm1Grg/Gata4+
involves: 129 * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Atrial septal defects and semilunar valve stenosis in Gata4tm1Grg/Gata4+ mice

cardiovascular system
• in 4 of 12 mutants
• increase in the frequency of mice with intermittent shunting of blood between the atria
• thickened aortic valve leaflets
• in 2 of 12 mutants
• thickened pulmonary valve leaflets

cellular

muscle

Mouse Models of Human Disease
OMIM IDRef(s)
Atrial Septal Defect 2; ASD2 607941 J:185124


Mouse Genome Informatics
cn3
    Gata4tm1Grg/Gata4tm1.1Wtp
Tg(Nkx2-5-cre)9Eno/0

involves: 129 * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Growth retardation and myocardial thinning in Gata4tm1.1Wtp/Gata4tm1Grg Tg(Nkx2-5-cre)9Eno/0 mice

mortality/aging

growth/size

cardiovascular system

embryogenesis


Mouse Genome Informatics
cn4
    Gata4tm1Grg/Gata4tm1.1Wtp
Tg(Myh6-cre)2182Mds/0

involves: 129 * C57BL/6 * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Hearts of Gata4tm1.1Wtp/Gata4tm1Grg Tg(Myh6-cre)2182Mds/0 mice appear normal

normal phenotype
• viable with no signs of embryonic growth retardation or myocardial thinning


Mouse Genome Informatics
cn5
    Gata4tm1Grg/Gata4tm1.1Wtp
Tg(Tek-cre)1Ywa/0

involves: 129 * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Hypocellular endocardial cushions in Gata4tm1.1Wtp/Gata4tm1Grg Tg(Tek-cre)1Ywa/0 mice

cardiovascular system
• hypocellular endocardial cushions are noted at E10.5
• however, no myocardial thinning is seen

growth/size
N
• viable with no signs of embryonic growth retardation (J:185124)