Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1Grg mutation
(1 available);
any
Gata4 mutation
(36 available)
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Growth retardation and a thin myocardium in Gata4tm1Grg/Gata4tm1Grg mice
mortality/aging
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• die between E10.5 and E11.5
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growth/size/body
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• severe growth retardation at E9.5 and E10.5
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cardiovascular system
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• severe thinning at E10.5
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• some embryos show delayed or incomplete looping at E9.5 and E10.5
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cellular
embryo
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• severe growth retardation at E9.5 and E10.5
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muscle
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• severe thinning at E10.5
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Allelic Composition |
Gata4tm1Grg/Gata4+
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Genetic Background |
involves: 129 * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1Grg mutation
(1 available);
any
Gata4 mutation
(36 available)
|
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Atrial septal defects and semilunar valve stenosis in Gata4tm1Grg/Gata4+ mice
cardiovascular system
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• increase in the frequency of mice with intermittent shunting of blood between the atria
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• thickened aortic valve leaflets
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• thickened pulmonary valve leaflets
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cellular
muscle
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Wtp mutation
(0 available);
any
Gata4 mutation
(36 available)
Gata4tm1Grg mutation
(1 available);
any
Gata4 mutation
(36 available)
Tg(Nkx2-5-cre)9Eno mutation
(0 available)
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Growth retardation and myocardial thinning in Gata4tm1.1Wtp/Gata4tm1Grg Tg(Nkx2-5-cre)9Eno/0 mice
mortality/aging
growth/size/body
cardiovascular system
embryo
muscle
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Wtp mutation
(0 available);
any
Gata4 mutation
(36 available)
Gata4tm1Grg mutation
(1 available);
any
Gata4 mutation
(36 available)
Tg(Myh6-cre)2182Mds mutation
(3 available)
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Hearts of Gata4tm1.1Wtp/Gata4tm1Grg Tg(Myh6-cre)2182Mds/0 mice appear normal
normal phenotype
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• viable with no signs of embryonic growth retardation or myocardial thinning
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Wtp mutation
(0 available);
any
Gata4 mutation
(36 available)
Gata4tm1Grg mutation
(1 available);
any
Gata4 mutation
(36 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
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Hypocellular endocardial cushions in Gata4tm1.1Wtp/Gata4tm1Grg Tg(Tek-cre)1Ywa/0 mice
cardiovascular system
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• hypocellular endocardial cushions are noted at E10.5
• however, no myocardial thinning is seen
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growth/size/body
N |
• viable with no signs of embryonic growth retardation
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