hm1

Gata4^tm1Grg/Gata4^tm1Grg
involves: 129 * C57BL/6

Key:
♀	phenotype observed in females	WTSI	Wellcome Trust Sanger Institute
♂	phenotype observed in males	Euro	Europhenome
N	normal phenotype

mortality/aging

complete embryonic lethality during organogenesis ( J:185124 )

• die between E10.5 and E11.5

growth/size

embryonic growth retardation ( J:185124 )

• severe growth retardation at E9.5 and E10.5

cardiovascular system

delayed heart looping ( J:185124 )

• some embryos show delayed or incomplete looping at E9.5 and E10.5

thin myocardium ( J:185124 )

• severe thinning at E10.5

thin ventricular wall ( J:185124 )

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E9.5

cellular

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E9.5

embryogenesis

embryonic growth retardation ( J:185124 )

• severe growth retardation at E9.5 and E10.5

muscle

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E9.5

ht2

Gata4^tm1Grg/Gata4⁺
involves: 129 * C57BL/6

Key:
♀	phenotype observed in females	WTSI	Wellcome Trust Sanger Institute
♂	phenotype observed in males	Euro	Europhenome
N	normal phenotype

cardiovascular system

abnormal heart atrium morphology ( J:185124 )

• thin

patent foramen ovale ( J:185124 )

• increase in the frequency of mice with intermittent shunting of blood between the atria

thin ventricle myocardium compact layer ( J:185124 )

thick aortic valve ( J:185124 )

• thickened aortic valve leaflets

thick pulmonary valve ( J:185124 )

• thickened pulmonary valve leaflets

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E11.5 and E13.5

cellular

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E11.5 and E13.5

muscle

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E11.5 and E13.5

Mouse Models of Human Disease		OMIM ID	Ref(s)
Atrial Septal Defect 2; ASD2		607941	J:185124

cn3

Gata4^tm1Grg/Gata4^tm1.1Wtp
Tg(Nkx2-5-cre)9Eno/0
involves: 129 * C57BL/6

Key:
♀	phenotype observed in females	WTSI	Wellcome Trust Sanger Institute
♂	phenotype observed in males	Euro	Europhenome
N	normal phenotype

mortality/aging

partial embryonic lethality during organogenesis ( J:185124 )

• at E10.5

growth/size

embryonic growth retardation ( J:185124 )

• severe

cardiovascular system

thin myocardium ( J:185124 )

embryogenesis

embryonic growth retardation ( J:185124 )

• severe

cn4

Gata4^tm1Grg/Gata4^tm1.1Wtp
Tg(Myh6-cre)2182Mds/0
involves: 129 * C57BL/6 * FVB/N

Key:
♀	phenotype observed in females	WTSI	Wellcome Trust Sanger Institute
♂	phenotype observed in males	Euro	Europhenome
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:185124 )

• viable with no signs of embryonic growth retardation or myocardial thinning

cn5

Gata4^tm1Grg/Gata4^tm1.1Wtp
Tg(Tek-cre)1Ywa/0
involves: 129 * C57BL/6 * SJL

Key:
♀	phenotype observed in females	WTSI	Wellcome Trust Sanger Institute
♂	phenotype observed in males	Euro	Europhenome
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:185124 )

• viable with no signs of embryonic growth retardation or myocardial thinning