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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gata4tm1Grg
targeted mutation 1, Vidu Garg
MGI:5427934
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gata4tm1Grg/Gata4tm1Grg involves: 129 * C57BL/6 MGI:5427935
ht2
Gata4tm1Grg/Gata4+ involves: 129 * C57BL/6 MGI:5427936
cn3
Gata4tm1Grg/Gata4tm1.1Wtp
Tg(Nkx2-5-cre)9Eno/0
involves: 129 * C57BL/6 MGI:5427940
cn4
Gata4tm1Grg/Gata4tm1.1Wtp
Tg(Myh6-cre)2182Mds/0
involves: 129 * C57BL/6 * FVB/N MGI:5427939
cn5
Gata4tm1Grg/Gata4tm1.1Wtp
Tg(Tek-cre)1Ywa/0
involves: 129 * C57BL/6 * SJL MGI:5427937


Genotype
MGI:5427935
hm1
Allelic
Composition
Gata4tm1Grg/Gata4tm1Grg
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1Grg mutation (1 available); any Gata4 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Growth retardation and a thin myocardium in Gata4tm1Grg/Gata4tm1Grg mice

mortality/aging

growth/size/body
• severe growth retardation at E9.5 and E10.5

cardiovascular system
• some embryos show delayed or incomplete looping at E9.5 and E10.5
• severe thinning at E10.5

cellular

embryo
• severe growth retardation at E9.5 and E10.5

muscle




Genotype
MGI:5427936
ht2
Allelic
Composition
Gata4tm1Grg/Gata4+
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1Grg mutation (1 available); any Gata4 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Atrial septal defects and semilunar valve stenosis in Gata4tm1Grg/Gata4+ mice

cardiovascular system
• in 4 of 12 mutants
• increase in the frequency of mice with intermittent shunting of blood between the atria
• thickened aortic valve leaflets
• in 2 of 12 mutants
• thickened pulmonary valve leaflets

cellular

muscle

Mouse Models of Human Disease
OMIM ID Ref(s)
Atrial Septal Defect 2; ASD2 607941 J:185124




Genotype
MGI:5427940
cn3
Allelic
Composition
Gata4tm1Grg/Gata4tm1.1Wtp
Tg(Nkx2-5-cre)9Eno/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Wtp mutation (0 available); any Gata4 mutation (15 available)
Gata4tm1Grg mutation (1 available); any Gata4 mutation (15 available)
Tg(Nkx2-5-cre)9Eno mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Growth retardation and myocardial thinning in Gata4tm1.1Wtp/Gata4tm1Grg Tg(Nkx2-5-cre)9Eno/0 mice

mortality/aging

growth/size/body

cardiovascular system

embryo




Genotype
MGI:5427939
cn4
Allelic
Composition
Gata4tm1Grg/Gata4tm1.1Wtp
Tg(Myh6-cre)2182Mds/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Wtp mutation (0 available); any Gata4 mutation (15 available)
Gata4tm1Grg mutation (1 available); any Gata4 mutation (15 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Hearts of Gata4tm1.1Wtp/Gata4tm1Grg Tg(Myh6-cre)2182Mds/0 mice appear normal

normal phenotype
• viable with no signs of embryonic growth retardation or myocardial thinning




Genotype
MGI:5427937
cn5
Allelic
Composition
Gata4tm1Grg/Gata4tm1.1Wtp
Tg(Tek-cre)1Ywa/0
Genetic
Background
involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Wtp mutation (0 available); any Gata4 mutation (15 available)
Gata4tm1Grg mutation (1 available); any Gata4 mutation (15 available)
Tg(Tek-cre)1Ywa mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Hypocellular endocardial cushions in Gata4tm1.1Wtp/Gata4tm1Grg Tg(Tek-cre)1Ywa/0 mice

cardiovascular system
• hypocellular endocardial cushions are noted at E10.5
• however, no myocardial thinning is seen

growth/size/body
N
• viable with no signs of embryonic growth retardation





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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory