Phenotypes associated with this allele

• Allele Symbol: Ctc1^tm1.1Schg
• Allele Name: targeted mutation 1.1, Sandy Chang
• Allele ID: MGI:5427642
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctc1^tm1.1Schg/Ctc1^tm1.1Schg	involves: 129S7/SvEvBrd * C57BL/6	MGI:5427705

Genotype
MGI:5427705

hm1

• Allelic Composition: Ctc1^tm1.1Schg/Ctc1^tm1.1Schg
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:184809 )

• median lifespan is 24 days

hematopoietic system

decreased splenocyte proliferation ( J:184809 )

small thymus ( J:184809 )

impaired hematopoiesis ( J:184809 )

• total absence

abnormal bone marrow cell morphology/development ( J:184809 )

• mice exhibit complete bone marrow failure and replacement by stromal adipose tissues unlike in wild-type mice

abnormal hematopoietic stem cell morphology ( J:184809 )

• fetal livers exhibit an increase in hematopoietic stem cells arrested in G2/M unlike in wild-type livers

• young mice exhibit abnormal hematopoietic stem cells in G2/M phase unlike in wild-type mice

decreased hematopoietic stem cell number ( J:184809 )

• 3-fold reduction in fetal livers

• severe depletion in mice

• however, young mice exhibit normal numbers of hematopoietic stem cells

small spleen ( J:184809 )

cellular

abnormal telomere length ( J:184809 )

• progressive telomere loss in mouse embryonic fibroblasts due to improper telomere replication

decreased cell proliferation ( J:184809 )

• in mouse embryonic fibroblast, spleen, skin, small intestine and testis cells

decreased fibroblast proliferation ( J:184809 )

decreased splenocyte proliferation ( J:184809 )

early cellular replicative senescence ( J:184809 )

• mouse embryonic fibroblasts exhibit a 20-fold increase in senescence-like phenotype compared with wild-type cells

abnormal DNA repair ( J:184809 )

• mouse embryonic fibroblasts lack DNA damage response

chromosomal instability ( J:184809 )

• 3-fold progressive increase in the number of chromosome fusions in mouse embryonic fibroblasts

homeostasis/metabolism

abnormal DNA repair ( J:184809 )

• mouse embryonic fibroblasts lack DNA damage response

growth/size/body

decreased body size ( J:184809 )

immune system

decreased splenocyte proliferation ( J:184809 )

small thymus ( J:184809 )

small spleen ( J:184809 )

integument

sparse hair ( J:184809 )

endocrine/exocrine glands

small thymus ( J:184809 )