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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pink1tm1Vbae
targeted mutation 1, Veerle Baekelandt
MGI:5319215
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pink1tm1Vbae/Pink1tm1Vbae involves: 129P2/OlaHsd * C57BL/6 MGI:5319217


Genotype
MGI:5319217
hm1
Allelic
Composition
Pink1tm1Vbae/Pink1tm1Vbae
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pink1tm1Vbae mutation (0 available); any Pink1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
N
• mouse embryonic fibroblasts exhibit normal cell growth
• mouse embryonic fibroblasts (MEFs) exhibit moderate mitochondrial fragmentation unlike in wild-type cells
• MEFs exhibit depolarized mitochondrial membrane potential compared with wild-type cells
• however, mitochondria exhibit normal respiratory complexes
• mouse embryonic fibroblasts exhibit altered cytosolic calcium metabolism under conditions of high ATP demand compared with wild-type cells
• mouse embryonic fibroblasts exhibit impaired stimulation of mitochondrial calcium uptake and ATP synthesis compared with wild-type cells
• brain cells exhibit reduced mitochondrial ATP levels compared with wild-type cells
• mouse embryonic fibroblasts exhibit increased levels of reactive oxygen species compared with wild-type cells





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory