Phenotypes associated with this allele

• Allele Symbol: Pink1^tm1Vbae
• Allele Name: targeted mutation 1, Veerle Baekelandt
• Allele ID: MGI:5319215
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pink1^tm1Vbae/Pink1^tm1Vbae	involves: 129P2/OlaHsd * C57BL/6	MGI:5319217

Genotype
MGI:5319217

hm1

• Allelic Composition: Pink1^tm1Vbae/Pink1^tm1Vbae
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:182977 )

N • mouse embryonic fibroblasts exhibit normal cell growth

abnormal mitochondrial morphology ( J:182977 )

• mouse embryonic fibroblasts (MEFs) exhibit moderate mitochondrial fragmentation unlike in wild-type cells

• MEFs exhibit depolarized mitochondrial membrane potential compared with wild-type cells

• however, mitochondria exhibit normal respiratory complexes

abnormal cell physiology ( J:182977 )

• mouse embryonic fibroblasts exhibit altered cytosolic calcium metabolism under conditions of high ATP demand compared with wild-type cells

abnormal mitochondrial physiology ( J:182977 )

• mouse embryonic fibroblasts exhibit impaired stimulation of mitochondrial calcium uptake and ATP synthesis compared with wild-type cells

• brain cells exhibit reduced mitochondrial ATP levels compared with wild-type cells

oxidative stress ( J:182977 )

• mouse embryonic fibroblasts exhibit increased levels of reactive oxygen species compared with wild-type cells