Mouse Genome Informatics
hm1
    Pink1tm1Vbae/Pink1tm1Vbae
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cellular
N
• mouse embryonic fibroblasts exhibit normal cell growth (J:182977)
• mouse embryonic fibroblasts (MEFs) exhibit moderate mitochondrial fragmentation unlike in wild-type cells
• MEFs exhibit depolarized mitochondrial membrane potential compared with wild-type cells
• however, mitochondria exhibit normal respiratory complexes
• mouse embryonic fibroblasts exhibit altered cytosolic calcium metabolism under conditions of high ATP demand compared with wild-type cells
• mouse embryonic fibroblasts exhibit impaired stimulation of mitochondrial calcium uptake and ATP synthesis compared with wild-type cells
• brain cells exhibit reduced mitochondrial ATP levels compared with wild-type cells
• mouse embryonic fibroblasts exhibit increased levels of reactive oxygen species compared with wild-type cells