Phenotypes associated with this allele

• Allele Symbol: Akt1^tm2.1Mbb
• Allele Name: targeted mutation 2.1, Morris J Birnbaum
• Allele ID: MGI:5317890
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akt1^tm2.1Mbb/Akt1^tm2.1Mbb	involves: 129S4/SvJae * C57BL/6J * FVB/N	MGI:5317895

Genotype
MGI:5317895

hm1

• Allelic Composition: Akt1^tm2.1Mbb/Akt1^tm2.1Mbb
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased fatty acid oxidation ( J:182721 )

• mice exhibit increased palmitate oxidation compared with control mice

decreased susceptibility to diet-induced obesity ( J:182721 )

• in mice fed a high fat diet

decreased circulating leptin level ( J:182721 )

• in mice fed a high fat diet

decreased circulating thyroxine level ( J:182721 )

• in mice fed a high fat diet

increased carbon dioxide production ( J:182721 )

• at 10 weeks of age in mice fed normal chow

increased oxygen consumption ( J:182721 )

• in mice fed a high fat diet

• at 10 weeks of age in mice fed normal chow

• at 21 to 22 weeks in mice fed normal chow when compared with weight-matched control mice

decreased respiratory quotient ( J:182721 )

• at 21 to 22 weeks during the dark cycle when compared with weight-matched control mice

abnormal glucose homeostasis ( J:182721 )

• mice fed a high fat diet exhibit elevated peripheral glucose utilization rate compared with control mice

abnormal gluconeogenesis ( J:182721 )

• mice fed a high fat diet exhibit decreased hepatic glucose production compared with control mice

improved glucose tolerance ( J:182721 )

• in mice fed a high fat diet

increased insulin sensitivity ( J:182721 )

• in mice fed a high fat diet

increased circulating adiponectin level ( J:182721 )

• in mice fed a high fat diet

decreased liver triglyceride level ( J:182721 )

• in mice fed a high fat diet

increased basal metabolism ( J:182721 )

• in mice fed a high fat diet

• at 10 weeks of age in mice fed normal chow

• at 21 to 22 weeks in mice fed normal chow when compared with weight-matched control mice

growth/size/body

decreased lean body mass ( J:182721 )

• in mice fed a high fat diet

• however, body composition at 10 weeks of age on normal chow is normal

decreased susceptibility to diet-induced obesity ( J:182721 )

• in mice fed a high fat diet

decreased body size ( J:182721 )

• at 10 weeks of age in mice fed normal chow

• however, body composition is normal

decreased body weight ( J:182721 )

• in mice fed a high fat diet

adipose tissue

decreased total body fat amount ( J:182721 )

• in mice fed a high fat diet

decreased percent body fat/body weight ( J:182721 )

• in mice fed a high fat diet

• however, body composition at 10 weeks of age on normal chow is normal

behavior/neurological

hyperactivity ( J:182721 )

• at 21 to 22 weeks during the dark cycle when compared with weight-matched control mice

liver/biliary system

decreased liver triglyceride level ( J:182721 )

• in mice fed a high fat diet

decreased susceptibility to diet-induced hepatic steatosis ( J:182721 )

• in mice fed a high fat diet

cellular

increased fatty acid oxidation ( J:182721 )

• mice exhibit increased palmitate oxidation compared with control mice