Mouse Genome Informatics
tg1
    Tg(CTSG-NUMA1/RARA)#Skr/0
involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• mutants exhibit myeloproliferation by 8 weeks of age and the myeloproliferation progresses to a nonfatal myeloproliferative disease-like myeloid leukemia with promyelocytic features by 6 months of age, which progresses to a myeloid leukemia with maturation in all mice older than 10 months of age

hematopoietic system
• mutants exhibit decreased total viable colony-forming unit, increased fraction of CFU-GM, decreased BFU-E and CFU-GEMM
• mutants exhibit a decrease in CFU-GEMM
• mutants exhibit a decrease in BFU-E
• all mutants over 4 months of age develop a peripheral blood myeloproliferative disorder, characterized by persistent neutrophilia, with mild leukocytosis, no anemia, and moderate thrombocytopenia, which becomes more severe with time
• increase in granulopoiesis in the bone marrow, with a progressive increase in promyelocytes and granulocytes
• persistent neutrophilia is seen in mice over 4 months of age
• moderate thrombocytopenia is seen in mutants over 4 months of age
• bone marrow is hypercellular
• infiltration of Gr1+, CD11b+, and CD117+ cells in the spleen
• leukemic infiltrates in the red pulp
• the oldest leukemic mutants exhibit enlarged spleens

immune system
• all mutants over 4 months of age develop a peripheral blood myeloproliferative disorder, characterized by persistent neutrophilia, with mild leukocytosis, no anemia, and moderate thrombocytopenia, which becomes more severe with time
• increase in granulopoiesis in the bone marrow, with a progressive increase in promyelocytes and granulocytes
• persistent neutrophilia is seen in mice over 4 months of age
• infiltration of Gr1+, CD11b+, and CD117+ cells in the spleen
• leukemic infiltrates in the red pulp
• the oldest leukemic mutants exhibit enlarged spleens

Mouse Models of Human Disease
OMIM IDRef(s)
Acute Promyelocytic Leukemia; APL 612376 J:88103