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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CTSG-NUMA1/RARA)#Skr
transgene insertion, Suzanne Kamel-Reid
MGI:5307058
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(CTSG-NUMA1/RARA)#Skr/0 involves: C57BL/6 MGI:5307063


Genotype
MGI:5307063
tg1
Allelic
Composition
Tg(CTSG-NUMA1/RARA)#Skr/0
Genetic
Background
involves: C57BL/6
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See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• mutants exhibit myeloproliferation by 8 weeks of age and the myeloproliferation progresses to a nonfatal myeloproliferative disease-like myeloid leukemia with promyelocytic features by 6 months of age, which progresses to a myeloid leukemia with maturation in all mice older than 10 months of age (J:88103)
• mutants exhibit myeloproliferation by 8 weeks of age and the myeloproliferation progresses to a nonfatal myeloproliferative disease-like myeloid leukemia with promyelocytic features by 6 months of age, which progresses to a myeloid leukemia with maturation in all mice older than 10 months of age (J:88103)

hematopoietic system
• mutants exhibit decreased total viable colony-forming unit, increased fraction of CFU-GM, decreased BFU-E and CFU-GEMM (J:88103)
• mutants exhibit decreased total viable colony-forming unit, increased fraction of CFU-GM, decreased BFU-E and CFU-GEMM (J:88103)
• mutants exhibit a decrease in CFU-GEMM (J:88103)
• mutants exhibit a decrease in CFU-GEMM (J:88103)
• bone marrow is hypercellular (J:88103)
• bone marrow is hypercellular (J:88103)
• mutants exhibit a decrease in BFU-E (J:88103)
• mutants exhibit a decrease in BFU-E (J:88103)
• moderate thrombocytopenia is seen in mutants over 4 months of age (J:88103)
• moderate thrombocytopenia is seen in mutants over 4 months of age (J:88103)
• all mutants over 4 months of age develop a peripheral blood myeloproliferative disorder, characterized by persistent neutrophilia, with mild leukocytosis, no anemia, and moderate thrombocytopenia, which becomes more severe with time (J:88103)
• all mutants over 4 months of age develop a peripheral blood myeloproliferative disorder, characterized by persistent neutrophilia, with mild leukocytosis, no anemia, and moderate thrombocytopenia, which becomes more severe with time (J:88103)
• increase in granulopoiesis in the bone marrow, with a progressive increase in promyelocytes and granulocytes (J:88103)
• increase in granulopoiesis in the bone marrow, with a progressive increase in promyelocytes and granulocytes (J:88103)
• persistent neutrophilia is seen in mice over 4 months of age (J:88103)
• persistent neutrophilia is seen in mice over 4 months of age (J:88103)
• infiltration of Gr1+, CD11b+, and CD117+ cells in the spleen (J:88103)
• infiltration of Gr1+, CD11b+, and CD117+ cells in the spleen (J:88103)
• leukemic infiltrates in the red pulp (J:88103)
• leukemic infiltrates in the red pulp (J:88103)
• the oldest leukemic mutants exhibit enlarged spleens (J:88103)
• the oldest leukemic mutants exhibit enlarged spleens (J:88103)

immune system
• all mutants over 4 months of age develop a peripheral blood myeloproliferative disorder, characterized by persistent neutrophilia, with mild leukocytosis, no anemia, and moderate thrombocytopenia, which becomes more severe with time (J:88103)
• all mutants over 4 months of age develop a peripheral blood myeloproliferative disorder, characterized by persistent neutrophilia, with mild leukocytosis, no anemia, and moderate thrombocytopenia, which becomes more severe with time (J:88103)
• increase in granulopoiesis in the bone marrow, with a progressive increase in promyelocytes and granulocytes (J:88103)
• increase in granulopoiesis in the bone marrow, with a progressive increase in promyelocytes and granulocytes (J:88103)
• persistent neutrophilia is seen in mice over 4 months of age (J:88103)
• persistent neutrophilia is seen in mice over 4 months of age (J:88103)
• infiltration of Gr1+, CD11b+, and CD117+ cells in the spleen (J:88103)
• infiltration of Gr1+, CD11b+, and CD117+ cells in the spleen (J:88103)
• leukemic infiltrates in the red pulp (J:88103)
• leukemic infiltrates in the red pulp (J:88103)
• the oldest leukemic mutants exhibit enlarged spleens (J:88103)
• the oldest leukemic mutants exhibit enlarged spleens (J:88103)

Mouse Models of Human Disease
OMIM ID Ref(s)
Acute Promyelocytic Leukemia; APL 612376 J:88103





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory