About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dpp6tm1.1Dahn
targeted mutation 1.1, Dax A Hoffman
MGI:5302080
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dpp6tm1.1Dahn/Dpp6tm1.1Dahn involves: C57BL/6 MGI:5302098


Genotype
MGI:5302098
hm1
Allelic
Composition
Dpp6tm1.1Dahn/Dpp6tm1.1Dahn
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dpp6tm1.1Dahn mutation (1 available); any Dpp6 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• enhanced due to slower A-current inactivation during repolarization
• CA1 pyramidal neuron apical dendrites are hyperexcitable compared with wild-type neurons
• however, somatic membrane excitability and GABAergic currents are normal
• neurons exhibit extended spike-timing window for long term potentiation compared with wild-type neurons
• mice lack the distal dendritic A-type potassium current gradient compared with wild-type mice
• calcium electrogenesis is enhanced in CA1 dendrites compared to in wild-type cells
• remaining A-type potassium channels in dendrites are Kcna4 mediated





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/12/2022
MGI 6.17
The Jackson Laboratory